Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thu...

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Veröffentlicht in:	Molecular psychiatry 2019-05, Vol.24 (5), p.757-771
Hauptverfasser:	de Vrij, Femke M., Bouwkamp, Christian G., Gunhanlar, Nilhan, Shpak, Guy, Lendemeijer, Bas, Baghdadi, Maarouf, Gopalakrishna, Shreekara, Ghazvini, Mehrnaz, Li, Tracy M., Quadri, Marialuisa, Olgiati, Simone, Breedveld, Guido J., Coesmans, Michiel, Mientjes, Edwin, de Wit, Ton, Verheijen, Frans W., Beverloo, H. Berna, Cohen, Dan, Kok, Rob M., Bakker, P. Roberto, Nijburg, Aviva, Spijker, Annet T., Haffmans, P. M. Judith, Hoencamp, Erik, Bergink, Veerle, Vorstman, Jacob A., Wu, Timothy, Olde Loohuis, Loes M., Amin, Najaf, Langen, Carolyn D., Hofman, Albert, Hoogendijk, Witte J., van Duijn, Cornelia M., Ikram, M. Arfan, Vernooij, Meike W., Tiemeier, Henning, Uitterlinden, André G., Elgersma, Ype, Distel, Ben, Gribnau, Joost, White, Tonya, Bonifati, Vincenzo, Kushner, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/51 14/19 38/23 59/57 631/208 631/532 692/699/476/1799 9/74 Adult Antigens - genetics Behavioral Sciences Biological Psychology Cell Differentiation - physiology Cell survival Chondroitin Chondroitin sulfate Chondroitin Sulfate Proteoglycans - genetics Chondroitin Sulfate Proteoglycans - metabolism Development and progression Diffusion Tensor Imaging Familial diseases Family Female Functional analysis Gene mutation Genetic aspects Glial stem cells Health aspects Humans Identification and classification Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Localization Magnetic resonance imaging Male Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Mental disorders Missense mutation Mutation Mutation - genetics Myelination Neuroimaging Neurophysiology Neurosciences Oligodendrocyte Precursor Cells - metabolism Oligodendrocyte Precursor Cells - physiology Oligodendroglia - metabolism Pedigree Pharmacotherapy Pluripotency Post-translation Progenitor cells Proteoglycans Proteoglycans - genetics Psychiatry Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Stem cells Substantia alba Sulfates Transfection Viability White Matter - metabolism
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