The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD

The tumor suppressor CYLD is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth–promoting NF-κB pathway. Missense mutations in the CYLD gene are present in individuals with syndromes such as multiple familial trichoepit...

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Veröffentlicht in:	The Journal of biological chemistry 2019-09, Vol.294 (38), p.14135-14148
Hauptverfasser:	Uematsu, Atsushi, Kido, Kohki, Takahashi, Hirotaka, Takahashi, Chikako, Yanagihara, Yuta, Saeki, Noritaka, Yoshida, Shuhei, Maekawa, Masashi, Honda, Mamoru, Kai, Tsutomu, Shimizu, Kouhei, Higashiyama, Shigeki, Imai, Yuuki, Tokunaga, Fuminori, Sawasaki, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoimmunity cellular immune response CYLD Cysteine Endopeptidases - metabolism Deubiquitinating Enzyme CYLD - metabolism Deubiquitinating Enzymes - metabolism Female HEK293 Cells HeLa Cells Humans inflammation Inflammation - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout mind bomb E3 ubiquitin protein ligase 2 mind bomb homologue 2 (MIB2) multiple familial trichoepithelioma (MFT) NF-kappa B (NF-KB) NF-kappa B - metabolism NF-κB pathway Polyubiquitin - metabolism Proteasome Endopeptidase Complex - metabolism protein array Protein Synthesis and Degradation Signal Transduction - physiology Transcription Factor RelA Tumor Necrosis Factor-alpha - metabolism ubiquitin Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination
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