A strategy for the selection of monovalent antibodies that span protein dimer interfaces

Ligand-induced dimerization is the predominant mechanism through which secreted proteins activate cell surface receptors to transmit essential biological signals. Cytokines are a large class of soluble proteins that dimerize transmembrane receptors into precise signaling topologies, but there is a n...

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Veröffentlicht in:	The Journal of biological chemistry 2019-09, Vol.294 (38), p.13876-13886
Hauptverfasser:	Spangler, Jamie B., Moraga, Ignacio, Jude, Kevin M., Savvides, Christina S., Garcia, K. Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics antibody engineering BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology cell signaling cytokine Dimerization directed evolution Editors' Picks Epitope Mapping - methods Epitopes - chemistry Humans immunology INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY interleukin-2 interleukin-4 ligand-receptor interactions Ligands Molecular Conformation Peptide Library Protein Binding - genetics Protein Engineering - methods Protein Multimerization - genetics Single-Chain Antibodies - genetics structural biology
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