Stewardship in sepsis

Sepsis is the major cause of mortality from any infectious disease worldwide. The goals of antimicrobial stewardship are to achieve optimum clinical outcomes and to ensure cost effectiveness and minimum unintended consequences, including toxic effects, selection of pathogenic organisms, and resistan...

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Veröffentlicht in:	Revista española de quimioterapia 2019-09, Vol.32 Suppl 2 (Suppl 2), p.42-46
1. Verfasser:	Del Pozo, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Antimicrobial Stewardship Humans Sepsis - drug therapy Sepsis - microbiology Update in Nosocomial Infection
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container_issue	Suppl 2
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container_title	Revista española de quimioterapia
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creator	Del Pozo, J L
description	Sepsis is the major cause of mortality from any infectious disease worldwide. The goals of antimicrobial stewardship are to achieve optimum clinical outcomes and to ensure cost effectiveness and minimum unintended consequences, including toxic effects, selection of pathogenic organisms, and resistance. The combination of inadequate diagnostic criteria for sepsis with the extraordinary time pressure to provide broad-spectrum antimicrobial therapy is troubling from a stewardship perspective. Use of empirical therapy according to guidelines, de-escalation of therapy, switch from intravenous to oral therapy, therapeutic drug monitoring, use of a list of restricted antibiotics, and bedside consultation can lead to significant benefits for clinical outcomes, adverse events, and costs.
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issn	0214-3429 1988-9518
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source	MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects	Anti-Bacterial Agents - therapeutic use Antimicrobial Stewardship Humans Sepsis - drug therapy Sepsis - microbiology Update in Nosocomial Infection
title	Stewardship in sepsis
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