Non-coding RNA in endothelial-to-mesenchymal transition
Abstract Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial matu...
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| Veröffentlicht in: | Cardiovascular research 2019-10, Vol.115 (12), p.1716-1731 |
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| container_title | Cardiovascular research |
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| creator | Hulshoff, Melanie S del Monte-Nieto, Gonzalo Kovacic, Jason Krenning, Guido |
| description | Abstract
Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease. |
| doi_str_mv | 10.1093/cvr/cvz211 |
| format | Article |
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Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.</description><identifier>ISSN: 0008-6363</identifier><identifier>ISSN: 1755-3245</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/cvz211</identifier><identifier>PMID: 31504268</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - pathology ; Cardiovascular Diseases - therapy ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Epithelial-Mesenchymal Transition - genetics ; Gene Expression Regulation ; Humans ; Phenotype ; Review Series from the 3rd Joint ESM-EVBO Conference 2019 ; RNA, Untranslated - genetics ; RNA, Untranslated - metabolism ; RNA, Untranslated - therapeutic use ; Signal Transduction</subject><ispartof>Cardiovascular research, 2019-10, Vol.115 (12), p.1716-1731</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-ce2a4c675eba0d4341f18eeb6705e365a27233b4d57d7be859e66a22f21fb54e3</citedby><cites>FETCH-LOGICAL-c515t-ce2a4c675eba0d4341f18eeb6705e365a27233b4d57d7be859e66a22f21fb54e3</cites><orcidid>0000-0001-5850-5667 ; 0000-0003-3830-2226</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31504268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hulshoff, Melanie S</creatorcontrib><creatorcontrib>del Monte-Nieto, Gonzalo</creatorcontrib><creatorcontrib>Kovacic, Jason</creatorcontrib><creatorcontrib>Krenning, Guido</creatorcontrib><title>Non-coding RNA in endothelial-to-mesenchymal transition</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Abstract
Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.</description><subject>Animals</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Cardiovascular Diseases - therapy</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Phenotype</subject><subject>Review Series from the 3rd Joint ESM-EVBO Conference 2019</subject><subject>RNA, Untranslated - genetics</subject><subject>RNA, Untranslated - metabolism</subject><subject>RNA, Untranslated - therapeutic use</subject><subject>Signal Transduction</subject><issn>0008-6363</issn><issn>1755-3245</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlYv_gDpRRBhNR87yfYiFPELREH0HLLZ2Taym9TNtqC_3ki16MXDMAzz8M7wEHLI6BmjE3FuV12qD87YFhkyBZAJnsM2GVJKi0wKKQZkL8bXNAKofJcMBAOac1kMiXoIPrOhcn42fnqYjp0fo69CP8fGmSbrQ9ZiRG_n761pxn1nfHS9C36f7NSmiXjw3Ufk5frq-fI2u3-8ubuc3mcWGPSZRW5yKxVgaWiVi5zVrEAspaKAQoLhigtR5hWoSpVYwASlNJzXnNUl5ChG5GKdu1iWLVYWffqh0YvOtaZ718E4_Xfj3VzPwkqnmyBApoCT74AuvC0x9rp10WLTGI9hGTXnRaF4cgcJPV2jtgsxdlhvzjCqv0zrZFqvTSf46PdjG_RHbQKO10BYLv4L-gTtPYfz</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Hulshoff, Melanie S</creator><creator>del Monte-Nieto, Gonzalo</creator><creator>Kovacic, Jason</creator><creator>Krenning, Guido</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5850-5667</orcidid><orcidid>https://orcid.org/0000-0003-3830-2226</orcidid></search><sort><creationdate>20191001</creationdate><title>Non-coding RNA in endothelial-to-mesenchymal transition</title><author>Hulshoff, Melanie S ; del Monte-Nieto, Gonzalo ; Kovacic, Jason ; Krenning, Guido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-ce2a4c675eba0d4341f18eeb6705e365a27233b4d57d7be859e66a22f21fb54e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Cardiovascular Diseases - therapy</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - pathology</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Phenotype</topic><topic>Review Series from the 3rd Joint ESM-EVBO Conference 2019</topic><topic>RNA, Untranslated - genetics</topic><topic>RNA, Untranslated - metabolism</topic><topic>RNA, Untranslated - therapeutic use</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hulshoff, Melanie S</creatorcontrib><creatorcontrib>del Monte-Nieto, Gonzalo</creatorcontrib><creatorcontrib>Kovacic, Jason</creatorcontrib><creatorcontrib>Krenning, Guido</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hulshoff, Melanie S</au><au>del Monte-Nieto, Gonzalo</au><au>Kovacic, Jason</au><au>Krenning, Guido</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-coding RNA in endothelial-to-mesenchymal transition</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>115</volume><issue>12</issue><spage>1716</spage><epage>1731</epage><pages>1716-1731</pages><issn>0008-6363</issn><issn>1755-3245</issn><eissn>1755-3245</eissn><abstract>Abstract
Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31504268</pmid><doi>10.1093/cvr/cvz211</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-5850-5667</orcidid><orcidid>https://orcid.org/0000-0003-3830-2226</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cardiovascular research, 2019-10, Vol.115 (12), p.1716-1731 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - therapy Endothelial Cells - metabolism Endothelial Cells - pathology Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation Humans Phenotype Review Series from the 3rd Joint ESM-EVBO Conference 2019 RNA, Untranslated - genetics RNA, Untranslated - metabolism RNA, Untranslated - therapeutic use Signal Transduction |
| title | Non-coding RNA in endothelial-to-mesenchymal transition |
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