Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging‑related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules...
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| Veröffentlicht in: | Molecular medicine reports 2019-10, Vol.20 (4), p.3701-3708 |
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| creator | Tsoukalas, Dimitris Fragkiadaki, Persefoni Docea, Anca Oana Alegakis, Athanasios K Sarandi, Evangelia Thanasoula, Maria Spandidos, Demetrios A Tsatsakis, Aristidis Razgonova, Mayya Petrovna Calina, Daniela |
| description | Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging‑related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti‑aging modulator that can play a role in the treatment of aging‑related diseases. This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA‑65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi‑nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above‑mentioned formulations were statistically significantly higher compared to those of the untreated cells. In particular, in order of importance with respect to telomerase activation from highest to lowest, 08AGTLF, OA, Nutrient 4, TA‑65, MA, Nutrient 3 and Nutrient 2, triggered statistically significant increase in telomerase activity compared to the untreated cells. 08AGTLF reached the highest levels of telomerase activity reported to date, at least to our knowledge, increasing telomerase activity by 8.8 folds compared to untreated cells, while Nutrient 4 and OA were also potent activators (4.3‑fold and 5.9‑fold increase, respectively). On the whole, this study indicates that the synergistic effect of nutrients and natural compounds can activate telomerase and produce more potent formulations. Human clinical studies using these formulations are required to evaluate their mode of action. This would reveal the health benefits of telomerase activation through natural molecules and would shed new light onto the treatment of aging‑related diseases. |
| doi_str_mv | 10.3892/mmr.2019.10614 |
| format | Article |
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Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti‑aging modulator that can play a role in the treatment of aging‑related diseases. This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA‑65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi‑nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above‑mentioned formulations were statistically significantly higher compared to those of the untreated cells. In particular, in order of importance with respect to telomerase activation from highest to lowest, 08AGTLF, OA, Nutrient 4, TA‑65, MA, Nutrient 3 and Nutrient 2, triggered statistically significant increase in telomerase activity compared to the untreated cells. 08AGTLF reached the highest levels of telomerase activity reported to date, at least to our knowledge, increasing telomerase activity by 8.8 folds compared to untreated cells, while Nutrient 4 and OA were also potent activators (4.3‑fold and 5.9‑fold increase, respectively). On the whole, this study indicates that the synergistic effect of nutrients and natural compounds can activate telomerase and produce more potent formulations. Human clinical studies using these formulations are required to evaluate their mode of action. This would reveal the health benefits of telomerase activation through natural molecules and would shed new light onto the treatment of aging‑related diseases.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2019.10614</identifier><identifier>PMID: 31485647</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Aging ; Amino acids ; Antioxidants ; Astragalus Plant - chemistry ; Cells, Cultured ; Cellular Senescence - drug effects ; Chronic obstructive pulmonary disease ; Clinical trials ; Deoxyribonucleic acid ; Dietary supplements ; DNA ; Drug Discovery ; Environmental factors ; Enzyme Activators - pharmacology ; Functional foods & nutraceuticals ; Health aspects ; Hormone replacement therapy ; Humans ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Medical research ; Mutation ; Nutrients ; Oleanolic acid ; Oleanolic Acid - pharmacology ; Oxidative stress ; Peripheral blood mononuclear cells ; Plant Extracts - pharmacology ; Retirement benefits ; Senescence ; Statistical analysis ; Studies ; Telomerase ; Telomerase - metabolism ; Telomere Shortening - drug effects ; Telomeres ; Triterpenes - pharmacology</subject><ispartof>Molecular medicine reports, 2019-10, Vol.20 (4), p.3701-3708</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Tsoukalas et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-4141425f69f34331b89552a31c9d7844a66a8e38e7612b4811fee1b5ce52b203</citedby><cites>FETCH-LOGICAL-c485t-4141425f69f34331b89552a31c9d7844a66a8e38e7612b4811fee1b5ce52b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsoukalas, Dimitris</creatorcontrib><creatorcontrib>Fragkiadaki, Persefoni</creatorcontrib><creatorcontrib>Docea, Anca Oana</creatorcontrib><creatorcontrib>Alegakis, Athanasios K</creatorcontrib><creatorcontrib>Sarandi, Evangelia</creatorcontrib><creatorcontrib>Thanasoula, Maria</creatorcontrib><creatorcontrib>Spandidos, Demetrios A</creatorcontrib><creatorcontrib>Tsatsakis, Aristidis</creatorcontrib><creatorcontrib>Razgonova, Mayya Petrovna</creatorcontrib><creatorcontrib>Calina, Daniela</creatorcontrib><title>Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging‑related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti‑aging modulator that can play a role in the treatment of aging‑related diseases. This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA‑65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi‑nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above‑mentioned formulations were statistically significantly higher compared to those of the untreated cells. In particular, in order of importance with respect to telomerase activation from highest to lowest, 08AGTLF, OA, Nutrient 4, TA‑65, MA, Nutrient 3 and Nutrient 2, triggered statistically significant increase in telomerase activity compared to the untreated cells. 08AGTLF reached the highest levels of telomerase activity reported to date, at least to our knowledge, increasing telomerase activity by 8.8 folds compared to untreated cells, while Nutrient 4 and OA were also potent activators (4.3‑fold and 5.9‑fold increase, respectively). On the whole, this study indicates that the synergistic effect of nutrients and natural compounds can activate telomerase and produce more potent formulations. Human clinical studies using these formulations are required to evaluate their mode of action. This would reveal the health benefits of telomerase activation through natural molecules and would shed new light onto the treatment of aging‑related diseases.</description><subject>Aging</subject><subject>Amino acids</subject><subject>Antioxidants</subject><subject>Astragalus Plant - chemistry</subject><subject>Cells, Cultured</subject><subject>Cellular Senescence - drug effects</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical trials</subject><subject>Deoxyribonucleic acid</subject><subject>Dietary supplements</subject><subject>DNA</subject><subject>Drug Discovery</subject><subject>Environmental factors</subject><subject>Enzyme Activators - pharmacology</subject><subject>Functional foods & nutraceuticals</subject><subject>Health aspects</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Medical research</subject><subject>Mutation</subject><subject>Nutrients</subject><subject>Oleanolic acid</subject><subject>Oleanolic Acid - pharmacology</subject><subject>Oxidative stress</subject><subject>Peripheral blood mononuclear cells</subject><subject>Plant Extracts - pharmacology</subject><subject>Retirement benefits</subject><subject>Senescence</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Telomerase</subject><subject>Telomerase - metabolism</subject><subject>Telomere Shortening - drug effects</subject><subject>Telomeres</subject><subject>Triterpenes - pharmacology</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptUU1rFTEUDWKxtbp1KQOu55nvDxdCqV-FQjd1HTOZO68pM5MxyXul_96MPquFcgkJuecczr0HoTcEb5g29P00pQ3FxGwIloQ_QydEGdIyjPnzw5sao47Ry5xvMZaCCvMCHTPCtZBcnaAfn0L2cQ_pvolDs8QCc2kKjHGC5DI0zpewdyWm_KH5Pg9x7MO8bWa4a8pNRSywK8E3bu7rKaF127W9QMoLrEzIr9DR4MYMrw_3Kbr-8vn6_Ft7efX14vzssvXVSmk5qUXFIM3AOGOk00YI6hjxpleacyel08A0KEloxzUhAwDphAdBO4rZKfr4R3bZdRP0vo6R3GiXFCaX7m10wT7uzOHGbuPeSiUEMbIKvDsIpPhzB7nY27hLc7VsKTVKa0Gp-ofauhFsqAupYn6qO7RnEgtDMFermc0TqFo9TMHHGYZQ_58i-BRzTjA8GCfYrjnbmrNdc7a_c66Et_-P-wD_Gyz7BXBuo_U</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Tsoukalas, Dimitris</creator><creator>Fragkiadaki, Persefoni</creator><creator>Docea, Anca Oana</creator><creator>Alegakis, Athanasios K</creator><creator>Sarandi, Evangelia</creator><creator>Thanasoula, Maria</creator><creator>Spandidos, Demetrios A</creator><creator>Tsatsakis, Aristidis</creator><creator>Razgonova, Mayya Petrovna</creator><creator>Calina, Daniela</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti‑aging modulator that can play a role in the treatment of aging‑related diseases. This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA‑65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi‑nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above‑mentioned formulations were statistically significantly higher compared to those of the untreated cells. In particular, in order of importance with respect to telomerase activation from highest to lowest, 08AGTLF, OA, Nutrient 4, TA‑65, MA, Nutrient 3 and Nutrient 2, triggered statistically significant increase in telomerase activity compared to the untreated cells. 08AGTLF reached the highest levels of telomerase activity reported to date, at least to our knowledge, increasing telomerase activity by 8.8 folds compared to untreated cells, while Nutrient 4 and OA were also potent activators (4.3‑fold and 5.9‑fold increase, respectively). On the whole, this study indicates that the synergistic effect of nutrients and natural compounds can activate telomerase and produce more potent formulations. Human clinical studies using these formulations are required to evaluate their mode of action. This would reveal the health benefits of telomerase activation through natural molecules and would shed new light onto the treatment of aging‑related diseases.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31485647</pmid><doi>10.3892/mmr.2019.10614</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2019-10, Vol.20 (4), p.3701-3708 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Amino acids Antioxidants Astragalus Plant - chemistry Cells, Cultured Cellular Senescence - drug effects Chronic obstructive pulmonary disease Clinical trials Deoxyribonucleic acid Dietary supplements DNA Drug Discovery Environmental factors Enzyme Activators - pharmacology Functional foods & nutraceuticals Health aspects Hormone replacement therapy Humans Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Medical research Mutation Nutrients Oleanolic acid Oleanolic Acid - pharmacology Oxidative stress Peripheral blood mononuclear cells Plant Extracts - pharmacology Retirement benefits Senescence Statistical analysis Studies Telomerase Telomerase - metabolism Telomere Shortening - drug effects Telomeres Triterpenes - pharmacology |
| title | Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives |
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