Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine

DNA double-strand breaks (DSBs) resulting from reactive oxygen species generated by exposure to UV and ionizing radiation are characterized by clusters of lesions near break sites. Such complex DSBs are repaired slowly, and their persistence can have severe consequences for human health. We have the...

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Veröffentlicht in:	Nucleic acids research 2019-09, Vol.47 (17), p.9410-9422
Hauptverfasser:	Kaminski, Andrea M, Chiruvella, Kishore K, Ramsden, Dale A, Kunkel, Thomas A, Bebenek, Katarzyna, Pedersen, Lars C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - genetics DNA Breaks, Double-Stranded - radiation effects DNA Damage - genetics DNA Damage - radiation effects DNA End-Joining Repair - genetics DNA End-Joining Repair - radiation effects DNA Ligase ATP - genetics DNA Replication - genetics DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - genetics Guanosine - analogs & derivatives Guanosine - genetics Humans Mutagenesis - radiation effects Radiation, Ionizing Reactive Oxygen Species - chemistry Structural Biology Ultraviolet Rays
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