Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions

The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphoryl...

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Veröffentlicht in:	Developmental biology 2019-11, Vol.455 (1), p.51-59
Hauptverfasser:	Xie, Baotong, Morton, David B., Cook, Tiffany A.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal development Animals binding sites Cell Differentiation - genetics Cell Line Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism enzymes gene expression Gene Expression Regulation, Developmental genes Hippo pathway Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism melting mutants Neuronal development neurons Neurons - cytology Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism opsin Photoreceptor Cells, Invertebrate - metabolism Photoreceptor specification photoreceptors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Rhodopsin - genetics Rhodopsin - metabolism RNA Processing, Post-Transcriptional Scalloped Sensory receptor exclusion Signal Transduction - genetics TAZ TEAD Trans-Activators - genetics Trans-Activators - metabolism transcription (genetics) transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic YAP Yorkie
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