Many human RNA viruses show extraordinarily stringent selective constraints on protein evolution

How negative selection, positive selection, and population size contribute to the large variation in nucleotide substitution rates among RNA viruses remains unclear. Here, we studied the ratios of nonsynonymous-to-synonymous substitution rates (d N/d S) in protein-coding genes of human RNA and DNA v...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-09, Vol.116 (38), p.19009-19018
Hauptverfasser:	Lin, Jinn-Jy, Bhattacharjee, Maloyjo Joyraj, Yu, Chun-Ping, Tseng, Yan Yuan, Li, Wen-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological evolution Biological Sciences DNA viruses Evolution, Molecular Exo-a-sialidase Genes Genome, Viral Genomes Hemagglutinins HIV Human immunodeficiency virus Humans Influenza A Mammals Mutation Mutation Rate Mutation rates Negative selection Nucleotides Population number Positive selection Proteins Ribonucleic acid RNA RNA Virus Infections - virology RNA viruses RNA Viruses - genetics Selection, Genetic Species Substitutes Vectors (Biology) Viral Proteins - genetics Viruses
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