Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

Accumulative aggregation of mutant Huntingtin (Htt) is a primary neuropathological hallmark of Huntington’s disease (HD). Currently, mechanistic understanding of the cytotoxicity of mutant Htt aggregates remains limited, and neuroprotective strategies combating mutant Htt-induced neurodegeneration a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-09, Vol.116 (38), p.19165-19175
Hauptverfasser:	Zhu, Yi, Li, Chong, Tao, Xianzun, Brazill, Jennifer M., Park, Joun, Diaz-Perez, Zoraida, Zhai, R. Grace
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenine Adhesives Age Agglomeration Aggregates Amyloid Amyloid - toxicity Animals Biological Sciences Clustering Cytotoxicity Drosophila melanogaster - drug effects Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Fruit flies Huntingtin Huntingtin Protein - genetics Huntingtin Protein - metabolism Huntington's disease Huntingtons disease Mitochondria Mutant Proteins - genetics Mutant Proteins - metabolism Mutation NAD Neurodegeneration Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - prevention & control Neuroprotection Neuroprotective Agents Neurotoxicity Nicotinamide Nicotinamide adenine dinucleotide Nicotinamide-Nucleotide Adenylyltransferase - genetics Nicotinamide-Nucleotide Adenylyltransferase - metabolism Phenotypes PNAS Plus Protein Aggregates Proteins Toxicity
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