Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for programmed RNA degradation by the 2-5A/RNase L complex in cells of all mammals. This 2-5A-mediated decay (2-5AMD) is a conserved stress response switching global protein synthesis from homeostasis to production of interferons (...

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Veröffentlicht in:	Molecular cell 2019-09, Vol.75 (6), p.1218-1228.e6
Hauptverfasser:	Rath, Sneha, Prangley, Eliza, Donovan, Jesse, Demarest, Kaitlin, Wingreen, Ned S., Meir, Yigal, Korennykh, Alexei
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells dsRNA Endoribonucleases - genetics Endoribonucleases - metabolism Humans Immunity, Innate innate immunity interferon mRNA decay Protein Biosynthesis reprogramming RNA Stability RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNase L Transcription, Genetic translation
Online-Zugang:	Volltext
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