Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Follicular regulatory T (T FR ) cells have specialized roles in modulating follicular helper T (T FH ) cell activation of B cells. However, the precise role of T FR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still unclear due to a lack of specific tools....

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Veröffentlicht in:	Nature immunology 2019-10, Vol.20 (10), p.1360-1371
Hauptverfasser:	Clement, Rachel L., Daccache, Joe, Mohammed, Mostafa T., Diallo, Alos, Blazar, Bruce R., Kuchroo, Vijay K., Lovitch, Scott B., Sharpe, Arlene H., Sage, Peter T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/2152 631/250/590 Allergens Analysis Animals Antibodies Antigens Antigens, Dermatophagoides - immunology Autoantigens Autoantigens - immunology B cells B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Cell activation Cell culture Cellular control mechanisms Clonal deletion Clonal Deletion - genetics Control Cytokines Disease Models, Animal Dust control Germinal Center - immunology House dust Humans Humoral immunity Hypersensitivity - immunology Immune response Immune Tolerance Immunity, Humoral Immunoglobulin E Immunoglobulin E - metabolism Immunoglobulin G Immunoglobulin G - metabolism Immunologic Memory Immunological memory Immunology Immunoregulation Infectious Diseases Inflammation Interleukin-13 - metabolism Lymphocyte Activation Lymphocytes Lymphocytes B Lymphocytes T Medical schools Mice Mice, Inbred C57BL Mice, Transgenic Mites Physiological aspects Pneumonia - immunology Pyroglyphidae - immunology T cells T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology Transcription factors Vaccines
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