Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate

Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations in prostate tumorigenesis is largely unknown....

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Veröffentlicht in:	Oncogene 2019-09, Vol.38 (38), p.6507-6520
Hauptverfasser:	He, Yongfeng, Johnson, Daniel T., Yang, Julie S., Wu, Huiqing, You, Sungyong, Yoon, Junhee, Lee, Dong-Hoon, Kim, Won Kyung, Aldahl, Joseph, Le, Vien, Hooker, Erika, Yu, Eun-Jeong, Geradts, Joseph, Cardiff, Robert D., Sun, Zijie
Format:	Artikel
Sprache:	eng
Schlagworte:	14/35 38/1 38/77 45/15 45/23 45/41 45/91 631/67/589/466 631/67/70 631/80/86/388 64/60 82/51 96/63 96/95 Androgen receptors Animal models Animals Apoptosis Basal cell carcinoma Care and treatment Cell Biology Cell Transformation, Neoplastic - genetics Cellular signal transduction Chromatin Clonal deletion Development and progression Disease Progression Epithelium Gene amplification Gene Deletion Gene Expression Regulation, Neoplastic Genetic aspects Genetic transformation Genomes Human Genetics Humans Immunoprecipitation Internal Medicine Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Molecular modelling Neoplasm Invasiveness Oncology p53 Protein Prostate cancer Prostate carcinoma Prostatic intraepithelial neoplasia Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptors, Androgen - genetics Receptors, Androgen - physiology Ribonucleic acid RNA RNA sequencing Signal Transduction - genetics SOXB1 Transcription Factors - physiology Transcription Transcriptome Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumorigenesis Tumors
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