Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans

•Larval stages are inconsistent for locomotion analysis; neuron scoring is more apt during larval stages.•Dopamine deficient strains retain some basal slowing.•The cat-2 mutants (e1112 and n4547) have differing levels of DA and cat-2 mRNA.•Neither of the cat-2 mutants (e1112 and n4547) is a null str...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2019-09, Vol.74, p.209-220
Hauptverfasser:	Smith, Latasha L., Ryde, Ian T., Hartman, Jessica H., Romersi, Riccardo F., Markovich, Zachary, Meyer, Joel N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Avoidance Learning - drug effects Behavior Behavior, Animal - drug effects Bends C. elegans Caenorhabditis elegans Caenorhabditis elegans Proteins cat-2 Cationic Amino Acid Transporter 2 - genetics Contaminants Cost analysis Dopamine Dopamine - deficiency Dopamine - metabolism Dopamine receptors Dopamine transporter Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Equipment costs Exploration Exploratory Behavior - drug effects Gene Expression Regulation Hydroxydopamines - toxicity Identification methods Larva Life span Locomotion Locomotion - drug effects Measurement methods Morphology mRNA Nematodes Nervous system Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - pathology Paralysis Screening Strains (organisms) Swimming Toxicants Worms
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