Epigenetic inhibition of the tumor suppressor ARHI by light at night‐induced circadian melatonin disruption mediates STAT3‐driven paclitaxel resistance in breast cancer

Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep‐wake cycles, is associated with a significantly increased risk of breast cancer and resistance to...

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Veröffentlicht in:	Journal of pineal research 2019-09, Vol.67 (2), p.e12586-n/a
Hauptverfasser:	Xiang, Shulin, Dauchy, Robert T., Hoffman, Aaron E., Pointer, David, Frasch, Tripp, Blask, David E., Hill, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology circadian disruption Circadian Rhythm - drug effects Drug Resistance, Neoplasm - drug effects Epigenesis, Genetic - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Humans MCF-7 Cells melatonin Melatonin - pharmacology Paclitaxel - pharmacology paclitaxel resistance Rats, Nude rho GTP-Binding Proteins - biosynthesis STAT3 Transcription Factor - metabolism STAT‐3 Tumor Suppressor Proteins - biosynthesis Xenograft Model Antitumor Assays
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