Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Viral glycoproteins are under constant immune surveillance by a host’s adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved to escape host immunity. Understanding how glycosylation affects immunodominance on complex prot...

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Veröffentlicht in:	Cell host & microbe 2019-06, Vol.25 (6), p.827-835.e6
Hauptverfasser:	Bajic, Goran, Maron, Max J., Adachi, Yu, Onodera, Taishi, McCarthy, Kevin R., McGee, Charles E., Sempowski, Gregory D., Takahashi, Yoshimasa, Kelsoe, Garnett, Kuraoka, Masayuki, Schmidt, Aaron G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Antibodies, Viral - metabolism broadly neutralizing antibodies Crystallography, X-Ray Epitopes - chemistry Epitopes - genetics Epitopes - immunology Epitopes - metabolism Glycosylation Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinin Glycoproteins, Influenza Virus - metabolism Immunization, Passive immunogen design Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - immunology influenza hemagglutinin Mice, Inbred BALB C Orthomyxoviridae Infections - prevention & control Polysaccharides - metabolism Protein Binding Protein Conformation protein engineering Survival Analysis
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