The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer

Cancer cells are known to upregulate aerobic glycolysis to promote growth, proliferation, and survival. However, the role of mitochondrial respiration in tumorigenesis remains elusive. Here we report that inhibition of mitochondrial function by silencing TFAM, a key transcription factor essential fo...

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Veröffentlicht in:	Cell death and differentiation 2019-10, Vol.26 (10), p.1955-1969
Hauptverfasser:	Wen, Yang-An, Xiong, Xiaopeng, Scott, Timothy, Li, Austin T., Wang, Chi, Weiss, Heidi L., Tan, Li, Bradford, Emily, Fan, Teresa W. M., Chandel, Navdeep S., Barrett, Terrence A., Gao, Tianyan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/89 13/95 38/39 631/67/2327 64/60 692/308/1426 82/80 Adenomatous polyposis coli Animal models Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell proliferation Colon cancer Colorectal cancer DNA biosynthesis Electron transport Gene silencing Glycolysis Hypoxia-inducible factor 1 Hypoxia-inducible factor 1a Intestine Ketoglutaric acid Life Sciences Metabolism Mitochondrial DNA Prolyl hydroxylase Respiration Retrograde transport Stem cell transplantation Stem Cells Tumorigenesis Wnt protein β-Catenin
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