Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients
Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the predict...
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| creator | Chen, Hung-Chun Chang, Jer-Ming Chiu, Yi-Wen Chen, Szu-Chia Lee, Wen-Hsien Lee, Jia-Jung Wu, Pei-Yu Su, Ho-Ming Huang, Jiun-Chi Hsu, Ya-Ling |
| description | Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and cardiovascular (CV) outcomes remains underexplored in hemodialysis (HD) patients. Methods. This prospective study included 190 maintenance HD patients. The E/E’sr ratio and GLS were assessed using two-dimensional speckle tracking echocardiography. The clinical outcomes included overall mortality, CV mortality, and major adverse cardiovascular events (MACE). The associations between the E/E’sr ratio, GLS, and clinical outcomes were evaluated using multivariate Cox regression analysis. The incremental values of the E/E’sr ratio and GLS in outcome prediction were assessed by χ2 changes in Cox models. Results. Over a median follow-up period of 3.7 years, there were 35 overall deaths, 16 CV deaths, and 45 MACE. Impaired diastolic function with a higher E/E’sr ratio was associated with overall mortality (HR, 1.484; 95% CI, 1.201−1.834; p |
| doi_str_mv | 10.1155/2019/7512805 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6748193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A606278536</galeid><sourcerecordid>A606278536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-791d28bcbc12256783984966dbee01a708cfad3807b3b4d1ae143d47919549233</originalsourceid><addsrcrecordid>eNqNks1uEzEURkcIREthxxpZYoMEof6bsb2pFIXQVkrUigJby2N7EkfOuNhOqjws74JHSVvKitUsvnPPnWt9VfUWwc8I1fUphkicshphDutn1THirB7xhsDn1THEjI8gpvCoepXSCkKEBRUvqyOCak4ggcfV728quwBCB6Yq-h2YuxyVB5d958Md-Gl90C7vQA4gLy0496Et6RenUg7eaXBTaNeDIrFA9eYemNkul-E-R6c3XkUwC_3C5Y1xfUlvdk-nr6M1TmdwtbVltwfzELPyw9pBOVerEMHYlDBZMFHRuLBVae-dbsuSBIrkwq6Dccrvkkvguhw1BK-rF53yyb45fE-qH1-n3ycXo9nV-eVkPBtpKkQeMYEM5q1uNcK4bhgnglPRNKa1FiLFINedMoRD1pKWGqQsosTQMiZqKjAhJ9XZ3nu7adfW6OFy5eVtdGsVdzIoJ58mvVvKRdjKhlGOxCD4cBDE8GtjU5Zrl7T1XvU2bJLEBCJKKYOooO__QVdhE8u7FgoLyBrMGX6kFspb6foulL16kMpxA5tSjJo0hfq0p3QMKUXbPfwygnJolxzaJQ_tKvi7v898gO_rVICPe2DpeqPu3H_qbGFspx5pRBkjnPwBaiXkSg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2290762872</pqid></control><display><type>article</type><title>Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><source>PubMed Central Free</source><source>MEDLINE</source><source>Free E-Journal (出版社公開部分のみ）</source><source>Alma/SFX Local Collection</source><creator>Chen, Hung-Chun ; Chang, Jer-Ming ; Chiu, Yi-Wen ; Chen, Szu-Chia ; Lee, Wen-Hsien ; Lee, Jia-Jung ; Wu, Pei-Yu ; Su, Ho-Ming ; Huang, Jiun-Chi ; Hsu, Ya-Ling</creator><contributor>Chadjichristos, Christos ; Christos Chadjichristos</contributor><creatorcontrib>Chen, Hung-Chun ; Chang, Jer-Ming ; Chiu, Yi-Wen ; Chen, Szu-Chia ; Lee, Wen-Hsien ; Lee, Jia-Jung ; Wu, Pei-Yu ; Su, Ho-Ming ; Huang, Jiun-Chi ; Hsu, Ya-Ling ; Chadjichristos, Christos ; Christos Chadjichristos</creatorcontrib><description>Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and cardiovascular (CV) outcomes remains underexplored in hemodialysis (HD) patients. Methods. This prospective study included 190 maintenance HD patients. The E/E’sr ratio and GLS were assessed using two-dimensional speckle tracking echocardiography. The clinical outcomes included overall mortality, CV mortality, and major adverse cardiovascular events (MACE). The associations between the E/E’sr ratio, GLS, and clinical outcomes were evaluated using multivariate Cox regression analysis. The incremental values of the E/E’sr ratio and GLS in outcome prediction were assessed by χ2 changes in Cox models. Results. Over a median follow-up period of 3.7 years, there were 35 overall deaths, 16 CV deaths, and 45 MACE. Impaired diastolic function with a higher E/E’sr ratio was associated with overall mortality (HR, 1.484; 95% CI, 1.201−1.834; p<0.001), CV mortality (HR, 1.584; 95% CI, 1.058–2.371; p=0.025), and MACE (HR, 1.205; 95% CI, 1.040−1.397; p=0.013) in multivariate adjusted Cox analysis. Worsening GLS was associated with overall mortality (HR, 1.276; 95% CI, 1.101−1.480; p=0.001), CV mortality (HR, 1.513; 95% CI, 1.088−2.104; p=0.014), and MACE (HR, 1.214; 95% CI, 1.103−1.337; p<0.001). The E/E’sr ratio and GLS had better outcome prediction than the E to early diastolic mitral annular velocity (E/E’) ratio and left ventricular ejection fraction (LVEF). Moreover, adding the E/E’sr ratio and GLS to Cox models containing relevant clinical and conventional echocardiographic parameters improved the prediction of overall mortality (p<0.001), CV mortality (p<0.001), and MACE (p<0.001). Conclusion. The E/E’sr ratio and GLS, as emerging indices of LV diastolic and systolic functions, significantly predict mortality and CV outcomes and outperform conventional echocardiographic parameters in outcome prediction in HD patients.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2019/7512805</identifier><identifier>PMID: 31583030</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Ankle ; Biomarkers - analysis ; Blood Flow Velocity ; Blood pressure ; Calcification ; Cardiology ; Cardiovascular diseases ; Dialysis ; Diastole ; Echocardiography ; Fatalities ; Female ; Heart ; Heart failure ; Heart Failure, Systolic - diagnosis ; Heart Failure, Systolic - etiology ; Heart Failure, Systolic - mortality ; Heart Failure, Systolic - physiopathology ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Hemodialysis ; Hospitals ; Humans ; Inflow ; Kidney diseases ; Laboratories ; Longitude ; Male ; Mathematical models ; Medical records ; Medical research ; Medicine, Experimental ; Middle Aged ; Mitral Valve - diagnostic imaging ; Mitral Valve - physiopathology ; Mortality ; Multivariate analysis ; Myocardial Infarction - diagnosis ; Myocardial Infarction - etiology ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Nephrology ; Parameters ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Regression analysis ; Renal Dialysis ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - therapy ; Strain rate ; Stroke Volume ; Systole ; Taiwan ; Velocity ; Ventricle ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - mortality ; Ventricular Dysfunction, Left - physiopathology ; X-rays</subject><ispartof>Disease markers, 2019, Vol.2019 (2019), p.1-12</ispartof><rights>Copyright © 2019 Jiun-Chi Huang et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Jiun-Chi Huang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Jiun-Chi Huang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-791d28bcbc12256783984966dbee01a708cfad3807b3b4d1ae143d47919549233</citedby><cites>FETCH-LOGICAL-c499t-791d28bcbc12256783984966dbee01a708cfad3807b3b4d1ae143d47919549233</cites><orcidid>0000-0003-4499-6631 ; 0000-0003-0071-1710 ; 0000-0002-5897-2860 ; 0000-0002-1610-4184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31583030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chadjichristos, Christos</contributor><contributor>Christos Chadjichristos</contributor><creatorcontrib>Chen, Hung-Chun</creatorcontrib><creatorcontrib>Chang, Jer-Ming</creatorcontrib><creatorcontrib>Chiu, Yi-Wen</creatorcontrib><creatorcontrib>Chen, Szu-Chia</creatorcontrib><creatorcontrib>Lee, Wen-Hsien</creatorcontrib><creatorcontrib>Lee, Jia-Jung</creatorcontrib><creatorcontrib>Wu, Pei-Yu</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Huang, Jiun-Chi</creatorcontrib><creatorcontrib>Hsu, Ya-Ling</creatorcontrib><title>Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and cardiovascular (CV) outcomes remains underexplored in hemodialysis (HD) patients. Methods. This prospective study included 190 maintenance HD patients. The E/E’sr ratio and GLS were assessed using two-dimensional speckle tracking echocardiography. The clinical outcomes included overall mortality, CV mortality, and major adverse cardiovascular events (MACE). The associations between the E/E’sr ratio, GLS, and clinical outcomes were evaluated using multivariate Cox regression analysis. The incremental values of the E/E’sr ratio and GLS in outcome prediction were assessed by χ2 changes in Cox models. Results. Over a median follow-up period of 3.7 years, there were 35 overall deaths, 16 CV deaths, and 45 MACE. Impaired diastolic function with a higher E/E’sr ratio was associated with overall mortality (HR, 1.484; 95% CI, 1.201−1.834; p<0.001), CV mortality (HR, 1.584; 95% CI, 1.058–2.371; p=0.025), and MACE (HR, 1.205; 95% CI, 1.040−1.397; p=0.013) in multivariate adjusted Cox analysis. Worsening GLS was associated with overall mortality (HR, 1.276; 95% CI, 1.101−1.480; p=0.001), CV mortality (HR, 1.513; 95% CI, 1.088−2.104; p=0.014), and MACE (HR, 1.214; 95% CI, 1.103−1.337; p<0.001). The E/E’sr ratio and GLS had better outcome prediction than the E to early diastolic mitral annular velocity (E/E’) ratio and left ventricular ejection fraction (LVEF). Moreover, adding the E/E’sr ratio and GLS to Cox models containing relevant clinical and conventional echocardiographic parameters improved the prediction of overall mortality (p<0.001), CV mortality (p<0.001), and MACE (p<0.001). Conclusion. The E/E’sr ratio and GLS, as emerging indices of LV diastolic and systolic functions, significantly predict mortality and CV outcomes and outperform conventional echocardiographic parameters in outcome prediction in HD patients.</description><subject>Aged</subject><subject>Ankle</subject><subject>Biomarkers - analysis</subject><subject>Blood Flow Velocity</subject><subject>Blood pressure</subject><subject>Calcification</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Dialysis</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Fatalities</subject><subject>Female</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart Failure, Systolic - diagnosis</subject><subject>Heart Failure, Systolic - etiology</subject><subject>Heart Failure, Systolic - mortality</subject><subject>Heart Failure, Systolic - physiopathology</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflow</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Longitude</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Mitral Valve - diagnostic imaging</subject><subject>Mitral Valve - physiopathology</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Nephrology</subject><subject>Parameters</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Strain rate</subject><subject>Stroke Volume</subject><subject>Systole</subject><subject>Taiwan</subject><subject>Velocity</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - mortality</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>X-rays</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNks1uEzEURkcIREthxxpZYoMEof6bsb2pFIXQVkrUigJby2N7EkfOuNhOqjws74JHSVvKitUsvnPPnWt9VfUWwc8I1fUphkicshphDutn1THirB7xhsDn1THEjI8gpvCoepXSCkKEBRUvqyOCak4ggcfV728quwBCB6Yq-h2YuxyVB5d958Md-Gl90C7vQA4gLy0496Et6RenUg7eaXBTaNeDIrFA9eYemNkul-E-R6c3XkUwC_3C5Y1xfUlvdk-nr6M1TmdwtbVltwfzELPyw9pBOVerEMHYlDBZMFHRuLBVae-dbsuSBIrkwq6Dccrvkkvguhw1BK-rF53yyb45fE-qH1-n3ycXo9nV-eVkPBtpKkQeMYEM5q1uNcK4bhgnglPRNKa1FiLFINedMoRD1pKWGqQsosTQMiZqKjAhJ9XZ3nu7adfW6OFy5eVtdGsVdzIoJ58mvVvKRdjKhlGOxCD4cBDE8GtjU5Zrl7T1XvU2bJLEBCJKKYOooO__QVdhE8u7FgoLyBrMGX6kFspb6foulL16kMpxA5tSjJo0hfq0p3QMKUXbPfwygnJolxzaJQ_tKvi7v898gO_rVICPe2DpeqPu3H_qbGFspx5pRBkjnPwBaiXkSg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Chen, Hung-Chun</creator><creator>Chang, Jer-Ming</creator><creator>Chiu, Yi-Wen</creator><creator>Chen, Szu-Chia</creator><creator>Lee, Wen-Hsien</creator><creator>Lee, Jia-Jung</creator><creator>Wu, Pei-Yu</creator><creator>Su, Ho-Ming</creator><creator>Huang, Jiun-Chi</creator><creator>Hsu, Ya-Ling</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4499-6631</orcidid><orcidid>https://orcid.org/0000-0003-0071-1710</orcidid><orcidid>https://orcid.org/0000-0002-5897-2860</orcidid><orcidid>https://orcid.org/0000-0002-1610-4184</orcidid></search><sort><creationdate>2019</creationdate><title>Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients</title><author>Chen, Hung-Chun ; Chang, Jer-Ming ; Chiu, Yi-Wen ; Chen, Szu-Chia ; Lee, Wen-Hsien ; Lee, Jia-Jung ; Wu, Pei-Yu ; Su, Ho-Ming ; Huang, Jiun-Chi ; Hsu, Ya-Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-791d28bcbc12256783984966dbee01a708cfad3807b3b4d1ae143d47919549233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Ankle</topic><topic>Biomarkers - analysis</topic><topic>Blood Flow Velocity</topic><topic>Blood pressure</topic><topic>Calcification</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Dialysis</topic><topic>Diastole</topic><topic>Echocardiography</topic><topic>Fatalities</topic><topic>Female</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart Failure, Systolic - diagnosis</topic><topic>Heart Failure, Systolic - etiology</topic><topic>Heart Failure, Systolic - mortality</topic><topic>Heart Failure, Systolic - physiopathology</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflow</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Longitude</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Mitral Valve - diagnostic imaging</topic><topic>Mitral Valve - physiopathology</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Nephrology</topic><topic>Parameters</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Strain rate</topic><topic>Stroke Volume</topic><topic>Systole</topic><topic>Taiwan</topic><topic>Velocity</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - mortality</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hung-Chun</creatorcontrib><creatorcontrib>Chang, Jer-Ming</creatorcontrib><creatorcontrib>Chiu, Yi-Wen</creatorcontrib><creatorcontrib>Chen, Szu-Chia</creatorcontrib><creatorcontrib>Lee, Wen-Hsien</creatorcontrib><creatorcontrib>Lee, Jia-Jung</creatorcontrib><creatorcontrib>Wu, Pei-Yu</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Huang, Jiun-Chi</creatorcontrib><creatorcontrib>Hsu, Ya-Ling</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hung-Chun</au><au>Chang, Jer-Ming</au><au>Chiu, Yi-Wen</au><au>Chen, Szu-Chia</au><au>Lee, Wen-Hsien</au><au>Lee, Jia-Jung</au><au>Wu, Pei-Yu</au><au>Su, Ho-Ming</au><au>Huang, Jiun-Chi</au><au>Hsu, Ya-Ling</au><au>Chadjichristos, Christos</au><au>Christos Chadjichristos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and cardiovascular (CV) outcomes remains underexplored in hemodialysis (HD) patients. Methods. This prospective study included 190 maintenance HD patients. The E/E’sr ratio and GLS were assessed using two-dimensional speckle tracking echocardiography. The clinical outcomes included overall mortality, CV mortality, and major adverse cardiovascular events (MACE). The associations between the E/E’sr ratio, GLS, and clinical outcomes were evaluated using multivariate Cox regression analysis. The incremental values of the E/E’sr ratio and GLS in outcome prediction were assessed by χ2 changes in Cox models. Results. Over a median follow-up period of 3.7 years, there were 35 overall deaths, 16 CV deaths, and 45 MACE. Impaired diastolic function with a higher E/E’sr ratio was associated with overall mortality (HR, 1.484; 95% CI, 1.201−1.834; p<0.001), CV mortality (HR, 1.584; 95% CI, 1.058–2.371; p=0.025), and MACE (HR, 1.205; 95% CI, 1.040−1.397; p=0.013) in multivariate adjusted Cox analysis. Worsening GLS was associated with overall mortality (HR, 1.276; 95% CI, 1.101−1.480; p=0.001), CV mortality (HR, 1.513; 95% CI, 1.088−2.104; p=0.014), and MACE (HR, 1.214; 95% CI, 1.103−1.337; p<0.001). The E/E’sr ratio and GLS had better outcome prediction than the E to early diastolic mitral annular velocity (E/E’) ratio and left ventricular ejection fraction (LVEF). Moreover, adding the E/E’sr ratio and GLS to Cox models containing relevant clinical and conventional echocardiographic parameters improved the prediction of overall mortality (p<0.001), CV mortality (p<0.001), and MACE (p<0.001). Conclusion. The E/E’sr ratio and GLS, as emerging indices of LV diastolic and systolic functions, significantly predict mortality and CV outcomes and outperform conventional echocardiographic parameters in outcome prediction in HD patients.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31583030</pmid><doi>10.1155/2019/7512805</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4499-6631</orcidid><orcidid>https://orcid.org/0000-0003-0071-1710</orcidid><orcidid>https://orcid.org/0000-0002-5897-2860</orcidid><orcidid>https://orcid.org/0000-0002-1610-4184</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6748193 |
| source | Open Access: Wiley-Blackwell Open Access Journals; PubMed Central Free; MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Aged Ankle Biomarkers - analysis Blood Flow Velocity Blood pressure Calcification Cardiology Cardiovascular diseases Dialysis Diastole Echocardiography Fatalities Female Heart Heart failure Heart Failure, Systolic - diagnosis Heart Failure, Systolic - etiology Heart Failure, Systolic - mortality Heart Failure, Systolic - physiopathology Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Hemodialysis Hospitals Humans Inflow Kidney diseases Laboratories Longitude Male Mathematical models Medical records Medical research Medicine, Experimental Middle Aged Mitral Valve - diagnostic imaging Mitral Valve - physiopathology Mortality Multivariate analysis Myocardial Infarction - diagnosis Myocardial Infarction - etiology Myocardial Infarction - mortality Myocardial Infarction - physiopathology Nephrology Parameters Prognosis Proportional Hazards Models Prospective Studies Regression analysis Renal Dialysis Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy Strain rate Stroke Volume Systole Taiwan Velocity Ventricle Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - mortality Ventricular Dysfunction, Left - physiopathology X-rays |
| title | Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A58%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ratio%20of%20Early%20Mitral%20Inflow%20Velocity%20to%20the%20Global%20Diastolic%20Strain%20Rate%20and%20Global%20Left%20Ventricular%20Longitudinal%20Systolic%20Strain%20Predict%20Overall%20Mortality%20and%20Major%20Adverse%20Cardiovascular%20Events%20in%20Hemodialysis%20Patients&rft.jtitle=Disease%20markers&rft.au=Chen,%20Hung-Chun&rft.date=2019&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=0278-0240&rft.eissn=1875-8630&rft_id=info:doi/10.1155/2019/7512805&rft_dat=%3Cgale_pubme%3EA606278536%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2290762872&rft_id=info:pmid/31583030&rft_galeid=A606278536&rfr_iscdi=true |