The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the activation of a PN gene signature. Besides prototypical ASCL1 PN t...

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Veröffentlicht in:	Cell death and differentiation 2019-09, Vol.26 (9), p.1813-1831
Hauptverfasser:	Narayanan, Ashwin, Gagliardi, Filippo, Gallotti, Alberto L., Mazzoleni, Stefania, Cominelli, Manuela, Fagnocchi, Luca, Pala, Mauro, Piras, Ignazio S., Zordan, Paola, Moretta, Nicole, Tratta, Elisa, Brugnara, Gianluca, Altabella, Luisa, Bozzuto, Giuseppina, Gorombei, Petra, Molinari, Agnese, Padua, Rose-Ann, Bulfone, Alessandro, Politi, Letterio S., Falini, Andrea, Castellano, Antonella, Mortini, Pietro, Zippo, Alessio, Poliani, Pietro L., Galli, Rossella
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/44 13/51 38/39 38/61 38/77 38/89 42 59/57 631/67/71 64 64/60 692/699/67/1922 82 82/80 Apoptosis ASCL1 protein Biochemistry Biomedical and Life Sciences Brain cancer Cell activation Cell Biology Cell Cycle Analysis Cell differentiation Cell self-renewal Glioblastoma Life Sciences Malignancy Mesenchyme Myc protein Neuronal-glial interactions Phenotypes Stem Cells Transcription Tumorigenesis
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