The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review

The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon secretion when plasma glucose concentrations...

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Veröffentlicht in:	International journal of molecular sciences 2019-08, Vol.20 (17), p.4092
Hauptverfasser:	Mathiesen, David S, Bagger, Jonatan I, Bergmann, Natasha C, Lund, Asger, Christensen, Mikkel B, Vilsbøll, Tina, Knop, Filip K
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Body weight Body weight loss Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Energy expenditure Energy intake Gastric Inhibitory Polypeptide - metabolism Gastric Inhibitory Polypeptide - pharmacology Glucagon Glucagon - biosynthesis Glucagon-like peptide 1 Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide-1 Receptor - agonists Glucose Humans Hyperglycemia Hypoglycemia Hypotheses Insulin Kinases Lipid metabolism Lipids Metabolism Metabolites Nervous system Pancreas Peptides Pharmacology Physiology Proteins Receptors, Gastrointestinal Hormone - agonists Review Weight loss
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