Nanomechanics of tip-link cadherins

Hearing and balance rely on the transduction of mechanical stimuli arising from sound waves or head movements into electrochemical signals. This archetypal mechanoelectrical transduction process occurs in the hair-cell stereocilia of the inner ear, which experience continuous oscillations driven by...

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Veröffentlicht in:	Scientific reports 2019-09, Vol.9 (1), p.13306-9, Article 13306
Hauptverfasser:	Oroz, Javier, Galera-Prat, Albert, Hervás, Rubén, Valbuena, Alejandro, Fernández-Bravo, Débora, Carrión-Vázquez, Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	631/57/2265 631/80/79/1902 82 Animals Cadherin 23 Cadherins Cadherins - metabolism Cadherins - physiology Calcium Cytoskeleton - metabolism Deafness Ear, Inner - metabolism Electrochemistry Hair Hair Cells, Auditory - metabolism Hearing - physiology Hearing loss HEK293 Cells Humanities and Social Sciences Humans Inner ear Mechanical properties Mechanical stimuli Mechanoreceptors Mechanotransduction Mechanotransduction, Cellular - physiology Mice multidisciplinary Mutation Oscillations Phenotypes Physiology Point mutation Protein Binding - physiology Protein Precursors - metabolism Protein Precursors - physiology Proteins Protocadherin Science Science (multidisciplinary) Signal transduction Sound waves Spectroscopy Spectrum analysis Stereocilia - metabolism Stereocilia - physiology
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