Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature
This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in four different drug classes. The associations between HAC and non-pharmacokinetic measures were generall...
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| Veröffentlicht in: | AIDS and behavior 2020-01, Vol.24 (1), p.311-330 |
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| creator | Zhang, Quan Qiao, Shan Yang, Xueying Li, Xiaoming |
| description | This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in four different drug classes. The associations between HAC and non-pharmacokinetic measures were generally lower than the association between HAC and other pharmacokinetic measures: the correlation coefficients (r) ranged from − 0.20 to 0.38 for self-report or pill counts and 0.20 to 0.85 for electronic drug monitoring; HAC and other pharmacokinetic measures were positively correlated with the correlation coefficients (
r
) ranging from 0.20 to 0.72, 0.34 to 0.86, 0.50 to 0.85 for antiretroviral concentration in plasma, peripheral blood mononuclear cells, and dried blood spots, respectively. HAC was one of the strongest independent predictors of virologic responses. HAC of tenofovir was significantly associated with renal toxicity in large sample studies. This review suggests that HAC is a valid biomarker of antiretroviral medication adherence. |
| doi_str_mv | 10.1007/s10461-019-02460-5 |
| format | Article |
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r
) ranging from 0.20 to 0.72, 0.34 to 0.86, 0.50 to 0.85 for antiretroviral concentration in plasma, peripheral blood mononuclear cells, and dried blood spots, respectively. HAC was one of the strongest independent predictors of virologic responses. HAC of tenofovir was significantly associated with renal toxicity in large sample studies. This review suggests that HAC is a valid biomarker of antiretroviral medication adherence.</description><identifier>ISSN: 1090-7165</identifier><identifier>EISSN: 1573-3254</identifier><identifier>DOI: 10.1007/s10461-019-02460-5</identifier><identifier>PMID: 30877582</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adhesion ; Adolescent ; Adult ; Aged ; Anti-HIV Agents - analysis ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Antiviral drugs ; Biomarkers ; Blood ; Blood levels ; Child ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Disease prevention ; Evidence-based medicine ; Female ; Hair ; Health Psychology ; HIV ; HIV Infections - drug therapy ; Human immunodeficiency virus ; Humans ; Infectious Diseases ; Leukocytes (mononuclear) ; Literature reviews ; Male ; Medication Adherence ; Medicine ; Medicine & Public Health ; Patient compliance ; Peripheral blood mononuclear cells ; Pharmacokinetics ; Pharmacology ; Prescription drugs ; Public Health ; Reviews ; Substantive Review ; Systematic review ; Tenofovir ; Therapeutic drug monitoring ; Toxicity</subject><ispartof>AIDS and behavior, 2020-01, Vol.24 (1), p.311-330</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>AIDS and Behavior is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-5d48cf424ff2ae8458148c84c3d70778056e7cc6f60738d39cf991787a181f793</citedby><cites>FETCH-LOGICAL-c540t-5d48cf424ff2ae8458148c84c3d70778056e7cc6f60738d39cf991787a181f793</cites><orcidid>0000-0001-6028-6977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10461-019-02460-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10461-019-02460-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27344,27924,27925,33774,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30877582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Qiao, Shan</creatorcontrib><creatorcontrib>Yang, Xueying</creatorcontrib><creatorcontrib>Li, Xiaoming</creatorcontrib><title>Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature</title><title>AIDS and behavior</title><addtitle>AIDS Behav</addtitle><addtitle>AIDS Behav</addtitle><description>This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in four different drug classes. The associations between HAC and non-pharmacokinetic measures were generally lower than the association between HAC and other pharmacokinetic measures: the correlation coefficients (r) ranged from − 0.20 to 0.38 for self-report or pill counts and 0.20 to 0.85 for electronic drug monitoring; HAC and other pharmacokinetic measures were positively correlated with the correlation coefficients (
r
) ranging from 0.20 to 0.72, 0.34 to 0.86, 0.50 to 0.85 for antiretroviral concentration in plasma, peripheral blood mononuclear cells, and dried blood spots, respectively. HAC was one of the strongest independent predictors of virologic responses. HAC of tenofovir was significantly associated with renal toxicity in large sample studies. This review suggests that HAC is a valid biomarker of antiretroviral medication adherence.</description><subject>Adhesion</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-HIV Agents - analysis</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiviral drugs</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Child</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Disease prevention</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Hair</subject><subject>Health Psychology</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Leukocytes (mononuclear)</subject><subject>Literature reviews</subject><subject>Male</subject><subject>Medication Adherence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patient compliance</subject><subject>Peripheral blood mononuclear cells</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Prescription drugs</subject><subject>Public Health</subject><subject>Reviews</subject><subject>Substantive Review</subject><subject>Systematic review</subject><subject>Tenofovir</subject><subject>Therapeutic drug monitoring</subject><subject>Toxicity</subject><issn>1090-7165</issn><issn>1573-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtv1TAQhSMEog_4AyyQJTbdBMbxmwXS1RVtkW6FxGNtuc64dZUbFzu5qGv-OC4pBbpgZcvznTMzPk3zgsJrCqDeFApc0haoaaHjElrxqNmnQrGWdYI_rncw0CoqxV5zUMoVABipzNNmj4FWSuhuv_mxGqeYccppF7MbyDqNHscpuymmkcSRnLqYiSvEkTN0Zc5IQsrkgeoM--gXyaq_xIzV5C1Zkc83ZcJtLXjyCXcRv5MUyMmQzqtmEyesbarjs-ZJcEPB53fnYfP1-P2X9Wm7-XjyYb3atF5wmFrRc-0D73gInUPNhab1QXPPegVKaRASlfcySFBM98z4YAxVWjmqaVCGHTbvFt_r-XyL_bLnYK9z3Lp8Y5OL9t_KGC_tRdpZqbjoVFcNju4Mcvo2Y5nsNhaPw-BGTHOxHTWMyvrHvKKvHqBXac5jXe-WoqqOLqBS3UL5nErJGO6HoWBvM7ZLxrZmbH9lbEUVvfx7jXvJ71ArwBag1NJ4gflP7__Y_gTAhrN-</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Zhang, Quan</creator><creator>Qiao, Shan</creator><creator>Yang, Xueying</creator><creator>Li, Xiaoming</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7T2</scope><scope>7U3</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHHNA</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HEHIP</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6028-6977</orcidid></search><sort><creationdate>20200101</creationdate><title>Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature</title><author>Zhang, Quan ; Qiao, Shan ; Yang, Xueying ; Li, Xiaoming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-5d48cf424ff2ae8458148c84c3d70778056e7cc6f60738d39cf991787a181f793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adhesion</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-HIV Agents - analysis</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral drugs</topic><topic>Antiviral drugs</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Child</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Disease prevention</topic><topic>Evidence-based medicine</topic><topic>Female</topic><topic>Hair</topic><topic>Health Psychology</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Leukocytes (mononuclear)</topic><topic>Literature reviews</topic><topic>Male</topic><topic>Medication Adherence</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Patient compliance</topic><topic>Peripheral blood mononuclear cells</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Prescription drugs</topic><topic>Public Health</topic><topic>Reviews</topic><topic>Substantive Review</topic><topic>Systematic review</topic><topic>Tenofovir</topic><topic>Therapeutic drug monitoring</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Qiao, Shan</creatorcontrib><creatorcontrib>Yang, Xueying</creatorcontrib><creatorcontrib>Li, Xiaoming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Social Services Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Sociological Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Sociology Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Criminal Justice Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Sociology Database (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Quan</au><au>Qiao, Shan</au><au>Yang, Xueying</au><au>Li, Xiaoming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature</atitle><jtitle>AIDS and behavior</jtitle><stitle>AIDS Behav</stitle><addtitle>AIDS Behav</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>24</volume><issue>1</issue><spage>311</spage><epage>330</epage><pages>311-330</pages><issn>1090-7165</issn><eissn>1573-3254</eissn><abstract>This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in four different drug classes. The associations between HAC and non-pharmacokinetic measures were generally lower than the association between HAC and other pharmacokinetic measures: the correlation coefficients (r) ranged from − 0.20 to 0.38 for self-report or pill counts and 0.20 to 0.85 for electronic drug monitoring; HAC and other pharmacokinetic measures were positively correlated with the correlation coefficients (
r
) ranging from 0.20 to 0.72, 0.34 to 0.86, 0.50 to 0.85 for antiretroviral concentration in plasma, peripheral blood mononuclear cells, and dried blood spots, respectively. HAC was one of the strongest independent predictors of virologic responses. HAC of tenofovir was significantly associated with renal toxicity in large sample studies. This review suggests that HAC is a valid biomarker of antiretroviral medication adherence.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30877582</pmid><doi>10.1007/s10461-019-02460-5</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0001-6028-6977</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adhesion Adolescent Adult Aged Anti-HIV Agents - analysis Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiviral drugs Biomarkers Blood Blood levels Child Correlation analysis Correlation coefficient Correlation coefficients Disease prevention Evidence-based medicine Female Hair Health Psychology HIV HIV Infections - drug therapy Human immunodeficiency virus Humans Infectious Diseases Leukocytes (mononuclear) Literature reviews Male Medication Adherence Medicine Medicine & Public Health Patient compliance Peripheral blood mononuclear cells Pharmacokinetics Pharmacology Prescription drugs Public Health Reviews Substantive Review Systematic review Tenofovir Therapeutic drug monitoring Toxicity |
| title | Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature |
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