Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis
Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10) gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a comprehensive meta-analysis was performed to evaluate the associa...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2019-07, Vol.20 (7), p.1951-1957 |
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| container_issue | 7 |
| container_start_page | 1951 |
| container_title | Asian Pacific Journal of Cancer Prevention |
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| creator | Jafari-Nedooshan, Jamal Moghimi, Mansour Zare, Mohammad Heiranizadeh, Naeimeh Morovati-Sharifabad, Majid Akbarian-Bafghi, Mohamad Javad Jarahzadeh, Mohammad Hossein Neamatzadeh, Hossein |
| description | Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)
gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a
comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10
gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases
was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence
intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with
4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism
was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI
1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=
1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,
there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.
Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer
among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might
be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G
polymorphisms are not significantly associated with increased risk of lung cancer. |
| doi_str_mv | 10.31557/APJCP.2019.20.7.1951 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6745207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31350950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3261-4d77b62fae25f969fd861bd524dbc7a3f489c3dab4bb6e49b79a399a37681f843</originalsourceid><addsrcrecordid>eNpVkctO4zAUhi00CBjgEUB-gXTs-BazGKmqZoBRERUXiZ1lO05rlMSV7YKy5clJYUCw8PGRz_k_Lz4ATjCaEMyY-DVd_JstJiXCciwTMcGS4R1wUFLBC8HLhx9f-n3wM6VHhCirBNsD-wQThiRDB-BlmlKwXmcfehgauIihC9lFeOOW26dFaIcuxPXKpy5tFy7nBUbw3PUOPvu8grebZN06e-NbnweYA5xv-iWc6d66eAZvh5RdN-LtSHzy7hnqvoZXLuti2ut2SD4dgd1Gt8kd_78Pwf3fP3ezi2J-fX45m84LS0qOC1oLYXjZaFeyRnLZ1BXHpmYlrY0VmjS0kpbU2lBjuKPSCKmJHI_gFW4qSg7B73fuemM6V1vX56hbtY6-03FQQXv1fdL7lVqGJ8UFZSUSI4C9A2wMKUXXfGYxUm9S1JsUtZUyFiXUVsqYO_368WfqwwJ5BczWjC8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Jafari-Nedooshan, Jamal ; Moghimi, Mansour ; Zare, Mohammad ; Heiranizadeh, Naeimeh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohamad Javad ; Jarahzadeh, Mohammad Hossein ; Neamatzadeh, Hossein</creator><creatorcontrib>Jafari-Nedooshan, Jamal ; Moghimi, Mansour ; Zare, Mohammad ; Heiranizadeh, Naeimeh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohamad Javad ; Jarahzadeh, Mohammad Hossein ; Neamatzadeh, Hossein</creatorcontrib><description>Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)
gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a
comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10
gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases
was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence
intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with
4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism
was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI
1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=
1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,
there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.
Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer
among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might
be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G
polymorphisms are not significantly associated with increased risk of lung cancer.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2019.20.7.1951</identifier><identifier>PMID: 31350950</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Genetic Predisposition to Disease ; Humans ; Interleukin-10 - genetics ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Polymorphism, Genetic ; Prognosis ; Promoter Regions, Genetic ; Review ; Risk Factors</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2019-07, Vol.20 (7), p.1951-1957</ispartof><rights>Asian Pacific Journal of Cancer Prevention</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3261-4d77b62fae25f969fd861bd524dbc7a3f489c3dab4bb6e49b79a399a37681f843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745207/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745207/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31350950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jafari-Nedooshan, Jamal</creatorcontrib><creatorcontrib>Moghimi, Mansour</creatorcontrib><creatorcontrib>Zare, Mohammad</creatorcontrib><creatorcontrib>Heiranizadeh, Naeimeh</creatorcontrib><creatorcontrib>Morovati-Sharifabad, Majid</creatorcontrib><creatorcontrib>Akbarian-Bafghi, Mohamad Javad</creatorcontrib><creatorcontrib>Jarahzadeh, Mohammad Hossein</creatorcontrib><creatorcontrib>Neamatzadeh, Hossein</creatorcontrib><title>Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)
gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a
comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10
gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases
was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence
intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with
4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism
was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI
1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=
1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,
there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.
Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer
among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might
be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G
polymorphisms are not significantly associated with increased risk of lung cancer.</description><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Interleukin-10 - genetics</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Polymorphism, Genetic</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic</subject><subject>Review</subject><subject>Risk Factors</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctO4zAUhi00CBjgEUB-gXTs-BazGKmqZoBRERUXiZ1lO05rlMSV7YKy5clJYUCw8PGRz_k_Lz4ATjCaEMyY-DVd_JstJiXCciwTMcGS4R1wUFLBC8HLhx9f-n3wM6VHhCirBNsD-wQThiRDB-BlmlKwXmcfehgauIihC9lFeOOW26dFaIcuxPXKpy5tFy7nBUbw3PUOPvu8grebZN06e-NbnweYA5xv-iWc6d66eAZvh5RdN-LtSHzy7hnqvoZXLuti2ut2SD4dgd1Gt8kd_78Pwf3fP3ezi2J-fX45m84LS0qOC1oLYXjZaFeyRnLZ1BXHpmYlrY0VmjS0kpbU2lBjuKPSCKmJHI_gFW4qSg7B73fuemM6V1vX56hbtY6-03FQQXv1fdL7lVqGJ8UFZSUSI4C9A2wMKUXXfGYxUm9S1JsUtZUyFiXUVsqYO_368WfqwwJ5BczWjC8</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Jafari-Nedooshan, Jamal</creator><creator>Moghimi, Mansour</creator><creator>Zare, Mohammad</creator><creator>Heiranizadeh, Naeimeh</creator><creator>Morovati-Sharifabad, Majid</creator><creator>Akbarian-Bafghi, Mohamad Javad</creator><creator>Jarahzadeh, Mohammad Hossein</creator><creator>Neamatzadeh, Hossein</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis</title><author>Jafari-Nedooshan, Jamal ; Moghimi, Mansour ; Zare, Mohammad ; Heiranizadeh, Naeimeh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohamad Javad ; Jarahzadeh, Mohammad Hossein ; Neamatzadeh, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3261-4d77b62fae25f969fd861bd524dbc7a3f489c3dab4bb6e49b79a399a37681f843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Interleukin-10 - genetics</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Polymorphism, Genetic</topic><topic>Prognosis</topic><topic>Promoter Regions, Genetic</topic><topic>Review</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jafari-Nedooshan, Jamal</creatorcontrib><creatorcontrib>Moghimi, Mansour</creatorcontrib><creatorcontrib>Zare, Mohammad</creatorcontrib><creatorcontrib>Heiranizadeh, Naeimeh</creatorcontrib><creatorcontrib>Morovati-Sharifabad, Majid</creatorcontrib><creatorcontrib>Akbarian-Bafghi, Mohamad Javad</creatorcontrib><creatorcontrib>Jarahzadeh, Mohammad Hossein</creatorcontrib><creatorcontrib>Neamatzadeh, Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jafari-Nedooshan, Jamal</au><au>Moghimi, Mansour</au><au>Zare, Mohammad</au><au>Heiranizadeh, Naeimeh</au><au>Morovati-Sharifabad, Majid</au><au>Akbarian-Bafghi, Mohamad Javad</au><au>Jarahzadeh, Mohammad Hossein</au><au>Neamatzadeh, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>20</volume><issue>7</issue><spage>1951</spage><epage>1957</epage><pages>1951-1957</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)
gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a
comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10
gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases
was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence
intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with
4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism
was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI
1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=
1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,
there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.
Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer
among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might
be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G
polymorphisms are not significantly associated with increased risk of lung cancer.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>31350950</pmid><doi>10.31557/APJCP.2019.20.7.1951</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Asian Pacific Journal of Cancer Prevention, 2019-07, Vol.20 (7), p.1951-1957 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals |
| subjects | Genetic Predisposition to Disease Humans Interleukin-10 - genetics Lung Neoplasms - etiology Lung Neoplasms - genetics Lung Neoplasms - pathology Polymorphism, Genetic Prognosis Promoter Regions, Genetic Review Risk Factors |
| title | Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis |
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