Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis

Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regulation are not entirely elucidated. The aim of this study was t...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2019, Vol.2019 (2019), p.1-17
Hauptverfasser:	Manea, Adrian, Muresian, Horia, Raicu, Monica, Lazar, Alexandra-Gela, Manea, Simona-Adriana, Vlad, Mihaela-Loredana, Simionescu, Maya
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Cell culture Diabetes E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - metabolism Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Genes Genetic transcription Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Histones Histones - biosynthesis Histones - genetics Histones - metabolism Humans Immunohistochemistry Kinases Laboratories Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - enzymology Macrophages - pathology Mitogens NADPH Oxidase 5 - biosynthesis NADPH Oxidase 5 - genetics NADPH Oxidase 5 - metabolism Oxidases Oxidative stress Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry THP-1 Cells Transcription factors Transfection Up-Regulation
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