BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas

The strong association between mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of loss on the DNA methylome in UM. Global DNA methylation was analyzed in 47 Class 1 and 45...

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Veröffentlicht in:	Clinical cancer research 2019-09, Vol.25 (18), p.5663-5673
Hauptverfasser:	Field, Matthew G, Kuznetsov, Jeffim N, Bussies, Parker L, Cai, Louie Z, Alawa, Karam A, Decatur, Christina L, Kurtenbach, Stefan, Harbour, J William
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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