The uric acid crystal receptor Clec12A potentiates type I interferon responses

The detection of microbes and damaged host cells by the innate immune system is essential for host defense against infection and tissue homeostasis. However, how distinct positive and negative regulatory signals from immune receptors are integrated to tailor specific responses in complex scenarios r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-09, Vol.116 (37), p.18544-18549
Hauptverfasser:	Li, Kai, Neumann, Konstantin, Duhan, Vikas, Namineni, Sukumar, Hansen, Anne Louise, Wartewig, Tim, Kurgyis, Zsuzsanna, Holm, Christian K., Heikenwalder, Mathias, Lang, Karl S., Ruland, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmins - immunology Animals Biological Sciences Cell death Chronic infection Crystals Cytosol - immunology Cytosol - metabolism Damage patterns DEAD Box Protein 58 - immunology DEAD Box Protein 58 - metabolism Detection Disease Models, Animal Homeostasis Humans Immune response Immune system Immunity, Innate Infections Inflammation Innate immunity Interferon Interferon regulatory factor 3 Interferon Regulatory Factor-3 - immunology Interferon Regulatory Factor-3 - metabolism Interferon Type I - immunology Interferon Type I - metabolism Kinases Lectins, C-Type - genetics Lectins, C-Type - immunology Lectins, C-Type - metabolism Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - immunology Mice Mice, Knockout Pathogen-Associated Molecular Pattern Molecules - immunology Protein-Serine-Threonine Kinases - immunology Protein-Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Receptors Receptors, Mitogen - genetics Receptors, Mitogen - immunology Receptors, Mitogen - metabolism Retinoic acid Ribonucleic acid RNA RNA - immunology RNA - metabolism Signal Transduction - immunology Signaling Spleen Syk protein Tyrosine Uric acid Uric Acid - immunology Viruses
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