The adhesion modulation domain of Caenorhabditis elegans α-catenin regulates actin binding during morphogenesis

Maintaining tissue integrity during epidermal morphogenesis depends on α-catenin, which connects the cadherin complex to F-actin. We show that the adhesion modulation domain (AMD) of HMP-1/α-catenin regulates its F-actin-binding activity and organization of junctional-proximal actin in vivo. Deletin...

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Veröffentlicht in:Molecular biology of the cell 2019-08, Vol.30 (17), p.2115-2123
Hauptverfasser: Shao, Xiangqiang, Lucas, Bethany, Strauch, Jared, Hardin, Jeff
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Sprache:eng
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