Ligand-Dependent Recruitment of the ErbB4 Signaling Complex into Neuronal Lipid Rafts

Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. In cultured cortical neurons, ErbB4 was rec...

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Veröffentlicht in:	The Journal of neuroscience 2003-04, Vol.23 (8), p.3164-3175
Hauptverfasser:	Ma, Li, Huang, Yang Z, Pitcher, Graham M, Valtschanoff, Juli G, Ma, Ying H, Feng, Lin Y, Lu, Bai, Xiong, Wen C, Salter, Michael W, Weinberg, Richard J, Mei, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Animals Brain Chemistry Cells, Cultured Disks Large Homolog 4 Protein ErbB4 protein GRB2 Adaptor Protein HER4 protein Humans Intracellular Signaling Peptides and Proteins Kidney - cytology Kidney - metabolism Ligands Long-Term Potentiation - physiology Macromolecular Substances Male Membrane Microdomains - metabolism Membrane Microdomains - ultrastructure Membrane Proteins microdomains Microscopy, Immunoelectron Mitogen-Activated Protein Kinases - metabolism Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - ultrastructure neuregulin Neuregulins - metabolism Neuregulins - pharmacology Neuronal Plasticity - physiology Neurons - drug effects Neurons - metabolism Neurons - ultrastructure Poisson Distribution Protein Structure, Tertiary - physiology Protein Transport - physiology Proteins - metabolism Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-4 Shc Signaling Adaptor Proteins Signal Transduction - physiology Src Homology 2 Domain-Containing, Transforming Protein 1
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