Functional NMDA Receptor Subtype 2B Is Expressed in Astrocytes after Ischemia In Vivo and Anoxia In Vitro

NMDA-type glutamate receptors play a critical role in neuronal synaptogenesis, plasticity, and excitotoxic death. Recent studies indicate that functional NMDA receptors are also expressed in certain glial populations in the normal brain. Using immunohistochemical methods, we detected the presence of...

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Veröffentlicht in:	The Journal of neuroscience 2003-04, Vol.23 (8), p.3364-3372
Hauptverfasser:	Krebs, Claudia, Fernandes, Herman B, Sheldon, Claire, Raymond, Lynn A, Baimbridge, Kenneth G
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Animals Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Axotomy Brain Ischemia - metabolism Calcium - metabolism Cell Hypoxia - physiology Cells, Cultured Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glial Fibrillary Acidic Protein - biosynthesis Hippocampus - cytology Hippocampus - metabolism Hippocampus - pathology Immunohistochemistry Male N-Methylaspartate - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Piperidines - pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - biosynthesis
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