Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord

Netrin-1, secreted by floor plate cells, orients axon extension in relation to the ventral midline of the embryonic spinal cord. Oligodendrocyte precursor (OP) cells are born close to the ventral midline and migrate away from the floor plate. Here we show that OP cells, identified by expression of t...

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Veröffentlicht in:	The Journal of neuroscience 2003-05, Vol.23 (9), p.3735-3744
Hauptverfasser:	Jarjour, Andrew A, Manitt, Colleen, Moore, Simon W, Thompson, Katherine M, Yuh, Sung-Joo, Kennedy, Timothy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - genetics Cell Count Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Chemotactic Factors - pharmacology Chemotactic Factors - physiology DCC Receptor deleted in colorectal carcinoma protein Diffusion Chambers, Culture Dose-Response Relationship, Drug Mice Mice, Inbred BALB C Mice, Mutant Strains Nerve Growth Factors - antagonists & inhibitors Nerve Growth Factors - pharmacology Nerve Growth Factors - physiology Netrin 1 Netrin Receptors Oligodendroglia - cytology Oligodendroglia - physiology Rats Rats, Sprague-Dawley Receptors, Cell Surface - biosynthesis Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - physiology Stem Cells - cytology Stem Cells - drug effects Stem Cells - physiology Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics
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