Hydrogen peroxide modulation of synaptic plasticity
Unlike the proposed role of reactive oxygen species in neurodegeneration, acute effects of reactive oxygen on synaptic plasticity are poorly understood. Using rat hippocampal slices, we found that exposure to a high concentration (0.5-5 mm) of H(2)O(2) reduces EPSPs in both potentiated and nonpotent...
Gespeichert in:
| Veröffentlicht in: | The Journal of neuroscience 2003-01, Vol.23 (1), p.269-276 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 276 |
|---|---|
| container_issue | 1 |
| container_start_page | 269 |
| container_title | The Journal of neuroscience |
| container_volume | 23 |
| creator | Kamsler, Ariel Segal, Menahem |
| description | Unlike the proposed role of reactive oxygen species in neurodegeneration, acute effects of reactive oxygen on synaptic plasticity are poorly understood. Using rat hippocampal slices, we found that exposure to a high concentration (0.5-5 mm) of H(2)O(2) reduces EPSPs in both potentiated and nonpotentiated synapses. Exposure of the slices to 20 microm H(2)O(2) did not affect expression of preestablished long-term potentiation (LTP) but prevented induction of new LTP and enhanced long-term depression (LTD). Surprisingly, 1 microm H(2)O(2) caused a twofold increase in LTP compared with controls, and it further enhanced NMDA-independent LTP. A low concentration of H(2)O(2) also suppressed LTD. Nifedipine, an L-type calcium channel blocker, did not affect control LTP but blocked effects of both 1 and 20 microm H(2)O(2). Calcineurin inhibitors [FK506 (FR900506) and cyclosporin A but not rapamycin] acted similarly and also restored LTP in the presence of 20 microm H(2)O(2). These results suggest that H(2)O(2) alters NMDA-independent, voltage-gated calcium channel-mediated LTP by activating calcineurin. |
| doi_str_mv | 10.1523/JNEUROSCI.23-01-00269.2003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6742148</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18759126</sourcerecordid><originalsourceid>FETCH-LOGICAL-p225t-3fa209e09ed2528439552e202d5d138b91bf35647de3520ec2a6eac48a28c54b3</originalsourceid><addsrcrecordid>eNqFkE1Lw0AURQdRbK3-BQku3CW-eTOTj40gpdpKsaB2HSaZSR1JMjGTiPn3BqyiK-HBXdzD5fAIuaAQUIHs6v5hsX3cPM1XATIfqA-AYRIgADsg05FIfORAD8kUMAI_5BGfkBPnXgEgAhodkwlFQTkinxK2HFRrd7r2Gt3aD6O0V1nVl7IztvZs4bmhlk1ncq8ppRvTdMMpOSpk6fTZPmdke7t4ni_99eZuNb9Z-w2i6HxWSIREj6dQYMxZIgRqBFRCURZnCc0KJkY9pZlA0DnKUMucxxLjXPCMzcj1127TZ5VWua67VpZp05pKtkNqpUn_NrV5SXf2PQ0jjpTH48DlfqC1b712XVoZl-uylLW2vUsjTLiAWPwL0jgSCcVwBM9_K_24fD-UfQJ47XsB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18759126</pqid></control><display><type>article</type><title>Hydrogen peroxide modulation of synaptic plasticity</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kamsler, Ariel ; Segal, Menahem</creator><creatorcontrib>Kamsler, Ariel ; Segal, Menahem</creatorcontrib><description>Unlike the proposed role of reactive oxygen species in neurodegeneration, acute effects of reactive oxygen on synaptic plasticity are poorly understood. Using rat hippocampal slices, we found that exposure to a high concentration (0.5-5 mm) of H(2)O(2) reduces EPSPs in both potentiated and nonpotentiated synapses. Exposure of the slices to 20 microm H(2)O(2) did not affect expression of preestablished long-term potentiation (LTP) but prevented induction of new LTP and enhanced long-term depression (LTD). Surprisingly, 1 microm H(2)O(2) caused a twofold increase in LTP compared with controls, and it further enhanced NMDA-independent LTP. A low concentration of H(2)O(2) also suppressed LTD. Nifedipine, an L-type calcium channel blocker, did not affect control LTP but blocked effects of both 1 and 20 microm H(2)O(2). Calcineurin inhibitors [FK506 (FR900506) and cyclosporin A but not rapamycin] acted similarly and also restored LTP in the presence of 20 microm H(2)O(2). These results suggest that H(2)O(2) alters NMDA-independent, voltage-gated calcium channel-mediated LTP by activating calcineurin.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.23-01-00269.2003</identifier><identifier>PMID: 12514224</identifier><language>eng</language><publisher>United States: Society for Neuroscience</publisher><subject>Animals ; Calcineurin - physiology ; Calcium Channels - physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Excitatory Postsynaptic Potentials ; Hippocampus - drug effects ; Hippocampus - physiology ; Hydrogen Peroxide - pharmacology ; Long-Term Potentiation - drug effects ; Long-Term Synaptic Depression - drug effects ; Male ; Neuronal Plasticity - drug effects ; Neurons - drug effects ; Neurons - physiology ; Rats ; Rats, Wistar ; Synaptic Transmission - drug effects</subject><ispartof>The Journal of neuroscience, 2003-01, Vol.23 (1), p.269-276</ispartof><rights>Copyright © 2003 Society for Neuroscience 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742148/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742148/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12514224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamsler, Ariel</creatorcontrib><creatorcontrib>Segal, Menahem</creatorcontrib><title>Hydrogen peroxide modulation of synaptic plasticity</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Unlike the proposed role of reactive oxygen species in neurodegeneration, acute effects of reactive oxygen on synaptic plasticity are poorly understood. Using rat hippocampal slices, we found that exposure to a high concentration (0.5-5 mm) of H(2)O(2) reduces EPSPs in both potentiated and nonpotentiated synapses. Exposure of the slices to 20 microm H(2)O(2) did not affect expression of preestablished long-term potentiation (LTP) but prevented induction of new LTP and enhanced long-term depression (LTD). Surprisingly, 1 microm H(2)O(2) caused a twofold increase in LTP compared with controls, and it further enhanced NMDA-independent LTP. A low concentration of H(2)O(2) also suppressed LTD. Nifedipine, an L-type calcium channel blocker, did not affect control LTP but blocked effects of both 1 and 20 microm H(2)O(2). Calcineurin inhibitors [FK506 (FR900506) and cyclosporin A but not rapamycin] acted similarly and also restored LTP in the presence of 20 microm H(2)O(2). These results suggest that H(2)O(2) alters NMDA-independent, voltage-gated calcium channel-mediated LTP by activating calcineurin.</description><subject>Animals</subject><subject>Calcineurin - physiology</subject><subject>Calcium Channels - physiology</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excitatory Postsynaptic Potentials</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Long-Term Synaptic Depression - drug effects</subject><subject>Male</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Synaptic Transmission - drug effects</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AURQdRbK3-BQku3CW-eTOTj40gpdpKsaB2HSaZSR1JMjGTiPn3BqyiK-HBXdzD5fAIuaAQUIHs6v5hsX3cPM1XATIfqA-AYRIgADsg05FIfORAD8kUMAI_5BGfkBPnXgEgAhodkwlFQTkinxK2HFRrd7r2Gt3aD6O0V1nVl7IztvZs4bmhlk1ncq8ppRvTdMMpOSpk6fTZPmdke7t4ni_99eZuNb9Z-w2i6HxWSIREj6dQYMxZIgRqBFRCURZnCc0KJkY9pZlA0DnKUMucxxLjXPCMzcj1127TZ5VWua67VpZp05pKtkNqpUn_NrV5SXf2PQ0jjpTH48DlfqC1b712XVoZl-uylLW2vUsjTLiAWPwL0jgSCcVwBM9_K_24fD-UfQJ47XsB</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Kamsler, Ariel</creator><creator>Segal, Menahem</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030101</creationdate><title>Hydrogen peroxide modulation of synaptic plasticity</title><author>Kamsler, Ariel ; Segal, Menahem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p225t-3fa209e09ed2528439552e202d5d138b91bf35647de3520ec2a6eac48a28c54b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Calcineurin - physiology</topic><topic>Calcium Channels - physiology</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excitatory Postsynaptic Potentials</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Long-Term Synaptic Depression - drug effects</topic><topic>Male</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Synaptic Transmission - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamsler, Ariel</creatorcontrib><creatorcontrib>Segal, Menahem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamsler, Ariel</au><au>Segal, Menahem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogen peroxide modulation of synaptic plasticity</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>23</volume><issue>1</issue><spage>269</spage><epage>276</epage><pages>269-276</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Unlike the proposed role of reactive oxygen species in neurodegeneration, acute effects of reactive oxygen on synaptic plasticity are poorly understood. Using rat hippocampal slices, we found that exposure to a high concentration (0.5-5 mm) of H(2)O(2) reduces EPSPs in both potentiated and nonpotentiated synapses. Exposure of the slices to 20 microm H(2)O(2) did not affect expression of preestablished long-term potentiation (LTP) but prevented induction of new LTP and enhanced long-term depression (LTD). Surprisingly, 1 microm H(2)O(2) caused a twofold increase in LTP compared with controls, and it further enhanced NMDA-independent LTP. A low concentration of H(2)O(2) also suppressed LTD. Nifedipine, an L-type calcium channel blocker, did not affect control LTP but blocked effects of both 1 and 20 microm H(2)O(2). Calcineurin inhibitors [FK506 (FR900506) and cyclosporin A but not rapamycin] acted similarly and also restored LTP in the presence of 20 microm H(2)O(2). These results suggest that H(2)O(2) alters NMDA-independent, voltage-gated calcium channel-mediated LTP by activating calcineurin.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>12514224</pmid><doi>10.1523/JNEUROSCI.23-01-00269.2003</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-6474 |
| ispartof | The Journal of neuroscience, 2003-01, Vol.23 (1), p.269-276 |
| issn | 0270-6474 1529-2401 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6742148 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Calcineurin - physiology Calcium Channels - physiology Cells, Cultured Dose-Response Relationship, Drug Excitatory Postsynaptic Potentials Hippocampus - drug effects Hippocampus - physiology Hydrogen Peroxide - pharmacology Long-Term Potentiation - drug effects Long-Term Synaptic Depression - drug effects Male Neuronal Plasticity - drug effects Neurons - drug effects Neurons - physiology Rats Rats, Wistar Synaptic Transmission - drug effects |
| title | Hydrogen peroxide modulation of synaptic plasticity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T01%3A43%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hydrogen%20peroxide%20modulation%20of%20synaptic%20plasticity&rft.jtitle=The%20Journal%20of%20neuroscience&rft.au=Kamsler,%20Ariel&rft.date=2003-01-01&rft.volume=23&rft.issue=1&rft.spage=269&rft.epage=276&rft.pages=269-276&rft.issn=0270-6474&rft.eissn=1529-2401&rft_id=info:doi/10.1523/JNEUROSCI.23-01-00269.2003&rft_dat=%3Cproquest_pubme%3E18759126%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18759126&rft_id=info:pmid/12514224&rfr_iscdi=true |