Opposing Roles of D1 and D2 Receptors in Appetitive Conditioning

Previous studies have shown that D(1) receptor blockade disrupts and D(2) receptor blockade enhances long-term potentiation. These data lead to the prediction that D(1) antagonists will attenuate and D(2) antagonists will potentiate at least some types of learning. The prediction is difficult to tes...

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Veröffentlicht in:	The Journal of neuroscience 2003-03, Vol.23 (5), p.1584-1587
Hauptverfasser:	Eyny, Yaniv S, Horvitz, Jon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Appetitive Behavior - drug effects Appetitive Behavior - physiology Behavior, Animal - drug effects Behavior, Animal - physiology Benzazepines - pharmacology Brief Communication Conditioning, Classical - drug effects Conditioning, Classical - physiology Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Learning - drug effects Learning - physiology Motor Activity - drug effects Motor Activity - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Raclopride - pharmacology Rats Rats, Sprague-Dawley Reaction Time - drug effects Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism
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