Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress
Uncontrollable shock produces a constellation of behavioral changes that are not observed after equivalent escapable shock. These include interference with escape and potentiation of fear conditioning. The activation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe n...
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| Veröffentlicht in: | The Journal of neuroscience 2003-02, Vol.23 (3), p.1019-1025 |
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| creator | Hammack, Sayamwong E Schmid, Megan J LoPresti, Matthew L Der-Avakian, Andre Pellymounter, Mary Ann Foster, Alan C Watkins, Linda R Maier, Steven F |
| description | Uncontrollable shock produces a constellation of behavioral changes that are not observed after equivalent escapable shock. These include interference with escape and potentiation of fear conditioning. The activation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe nucleus (DRN) during inescapable tailshock (IS) has been shown to be critical for the development of these behavioral changes. CRH binds to two receptor subtypes, both of which are found in the DRN. The present set of studies examined which CRH receptor subtype mediates the effects of IS. Intra-DRN administration of the CRH(2) receptor antagonist anti-sauvagine-30 before IS dose-dependently blocked IS-induced behavioral changes; the CRH(1) receptor antagonist 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine (NBI27914), administered in the same manner, did not. Moreover, the highly selective CRH(2) receptor agonist urocortin II (Ucn II) dose-dependently caused behavioral changes associated with IS in the absence of shock. Ucn II was effective at doses 100-fold lower than those previously required for CRH. The relationship between CRH(2) receptors and DRN 5-HT is discussed. |
| doi_str_mv | 10.1523/jneurosci.23-03-01019.2003 |
| format | Article |
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These include interference with escape and potentiation of fear conditioning. The activation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe nucleus (DRN) during inescapable tailshock (IS) has been shown to be critical for the development of these behavioral changes. CRH binds to two receptor subtypes, both of which are found in the DRN. The present set of studies examined which CRH receptor subtype mediates the effects of IS. Intra-DRN administration of the CRH(2) receptor antagonist anti-sauvagine-30 before IS dose-dependently blocked IS-induced behavioral changes; the CRH(1) receptor antagonist 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine (NBI27914), administered in the same manner, did not. Moreover, the highly selective CRH(2) receptor agonist urocortin II (Ucn II) dose-dependently caused behavioral changes associated with IS in the absence of shock. Ucn II was effective at doses 100-fold lower than those previously required for CRH. The relationship between CRH(2) receptors and DRN 5-HT is discussed.</description><identifier>ISSN: 0270-6474</identifier><identifier>ISSN: 1529-2401</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/jneurosci.23-03-01019.2003</identifier><identifier>PMID: 12574432</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Amygdala - drug effects ; Amygdala - physiology ; Aniline Compounds - pharmacology ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Corticotropin-Releasing Hormone - pharmacology ; Dose-Response Relationship, Drug ; Electroshock ; Escape Reaction - drug effects ; Escape Reaction - physiology ; Fear - physiology ; Helplessness, Learned ; Male ; Microinjections ; Motor Activity - drug effects ; Motor Activity - physiology ; Peptide Fragments - pharmacology ; Pyrimidines - pharmacology ; Raphe Nuclei - drug effects ; Raphe Nuclei - metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone - agonists ; Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors ; Receptors, Corticotropin-Releasing Hormone - metabolism ; Serotonin - metabolism ; Stress, Physiological - physiopathology ; Urocortins</subject><ispartof>The Journal of neuroscience, 2003-02, Vol.23 (3), p.1019-1025</ispartof><rights>Copyright © 2003 Society for Neuroscience 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-133faca9b9516b5b35bce116e68ec2cd9968dfcd23269a74f67b6175e8a046003</citedby><cites>FETCH-LOGICAL-c607t-133faca9b9516b5b35bce116e68ec2cd9968dfcd23269a74f67b6175e8a046003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741923/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741923/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12574432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammack, Sayamwong E</creatorcontrib><creatorcontrib>Schmid, Megan J</creatorcontrib><creatorcontrib>LoPresti, Matthew L</creatorcontrib><creatorcontrib>Der-Avakian, Andre</creatorcontrib><creatorcontrib>Pellymounter, Mary Ann</creatorcontrib><creatorcontrib>Foster, Alan C</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><title>Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Uncontrollable shock produces a constellation of behavioral changes that are not observed after equivalent escapable shock. These include interference with escape and potentiation of fear conditioning. The activation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe nucleus (DRN) during inescapable tailshock (IS) has been shown to be critical for the development of these behavioral changes. CRH binds to two receptor subtypes, both of which are found in the DRN. The present set of studies examined which CRH receptor subtype mediates the effects of IS. Intra-DRN administration of the CRH(2) receptor antagonist anti-sauvagine-30 before IS dose-dependently blocked IS-induced behavioral changes; the CRH(1) receptor antagonist 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine (NBI27914), administered in the same manner, did not. Moreover, the highly selective CRH(2) receptor agonist urocortin II (Ucn II) dose-dependently caused behavioral changes associated with IS in the absence of shock. Ucn II was effective at doses 100-fold lower than those previously required for CRH. The relationship between CRH(2) receptors and DRN 5-HT is discussed.</description><subject>Amygdala - drug effects</subject><subject>Amygdala - physiology</subject><subject>Aniline Compounds - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electroshock</subject><subject>Escape Reaction - drug effects</subject><subject>Escape Reaction - physiology</subject><subject>Fear - physiology</subject><subject>Helplessness, Learned</subject><subject>Male</subject><subject>Microinjections</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Peptide Fragments - pharmacology</subject><subject>Pyrimidines - pharmacology</subject><subject>Raphe Nuclei - drug effects</subject><subject>Raphe Nuclei - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Corticotropin-Releasing Hormone - agonists</subject><subject>Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Receptors, Corticotropin-Releasing Hormone - metabolism</subject><subject>Serotonin - metabolism</subject><subject>Stress, Physiological - physiopathology</subject><subject>Urocortins</subject><issn>0270-6474</issn><issn>1529-2401</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAUtBAVXQp_AVkcuGXxR2JvOCBBKLRVaaVt92w5zsvGlTcOdtJVfwL_GoeuKJyQnmQ_vXnjGQ9CbylZ0oLx93c9TMFHY5eMZyQVJbRcMkL4M7RIiDJjOaHP0YIwSTKRy_wYvYzxjhAiCZUv0DFlhcxzzhboZ-XDaI0fgx9sj9fgQEfbb_GZDzvfA759GACzNDAwjD5EnFBjB_hLumuH13pIzdVkHEwRf4fG6hF-Az5Dp--tDwlU-T7Cjwl6AxH7Fm964_v0onO6doBvxgAxvkJHrXYRXh_OE7T5enpbnWWX19_Oq0-XmRFEjhnlvNVGl3VZUFEXNS9qA5QKECswzDRlKVZNaxrGmSi1zFsha0FlAStNcpH-6AR9fOQdpnoHjYGkRDs1BLvT4UF5bdW_k952auvvlZA5LRlPBO8OBMEnU3FUOxsNJDM9-CkqyQnlrPg_kK5kwQWdJX14BJoUawzQ_lFDiZojVxdXp5v19U11rlJDUs2RqznytPzmbz9Pq4eMn2R0dtvtbQAVd9q5BKdqv98nQq5mOv4LBsG6pw</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Hammack, Sayamwong E</creator><creator>Schmid, Megan J</creator><creator>LoPresti, Matthew L</creator><creator>Der-Avakian, Andre</creator><creator>Pellymounter, Mary Ann</creator><creator>Foster, Alan C</creator><creator>Watkins, Linda R</creator><creator>Maier, Steven F</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030201</creationdate><title>Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress</title><author>Hammack, Sayamwong E ; 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These include interference with escape and potentiation of fear conditioning. The activation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe nucleus (DRN) during inescapable tailshock (IS) has been shown to be critical for the development of these behavioral changes. CRH binds to two receptor subtypes, both of which are found in the DRN. The present set of studies examined which CRH receptor subtype mediates the effects of IS. Intra-DRN administration of the CRH(2) receptor antagonist anti-sauvagine-30 before IS dose-dependently blocked IS-induced behavioral changes; the CRH(1) receptor antagonist 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine (NBI27914), administered in the same manner, did not. Moreover, the highly selective CRH(2) receptor agonist urocortin II (Ucn II) dose-dependently caused behavioral changes associated with IS in the absence of shock. Ucn II was effective at doses 100-fold lower than those previously required for CRH. The relationship between CRH(2) receptors and DRN 5-HT is discussed.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>12574432</pmid><doi>10.1523/jneurosci.23-03-01019.2003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala - drug effects Amygdala - physiology Aniline Compounds - pharmacology Animals Behavior, Animal - drug effects Behavior, Animal - physiology Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Electroshock Escape Reaction - drug effects Escape Reaction - physiology Fear - physiology Helplessness, Learned Male Microinjections Motor Activity - drug effects Motor Activity - physiology Peptide Fragments - pharmacology Pyrimidines - pharmacology Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - agonists Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - metabolism Serotonin - metabolism Stress, Physiological - physiopathology Urocortins |
| title | Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress |
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