De novo MET amplification promotes intrinsic resistance to first-generation EGFR tyrosine kinase inhibitors

First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) could induce dramatic tumor responses in non-small-cell lung cancer patients with EGFR-activating mutations. However, a small proportion of patients have no tumor response on initial EGFR TKI treatment with an...

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Veröffentlicht in:	Cancer biology & therapy 2019, Vol.20 (9), p.1183-1186
Hauptverfasser:	Li, Jing-Wen, Cao, Shu-Hui, Xu, Jian-Lin, Zhong, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Bedside-to-Bench Report
Online-Zugang:	Volltext
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