Ensaculin (KA‐672. HCl): A Multitransmitter Approach to Dementia Treatment

ABSTRACT Ensaculin, a novel benzopyranone substituted with a piperazine moiety, showed memory‐enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CNS drug reviews 2002-06, Vol.8 (2), p.143-158
Hauptverfasser:	Hoerr, Robert, Noeldner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	5HT7 5‐HT1A Animals Benzopyranone Benzopyrans - pharmacokinetics Benzopyrans - pharmacology Benzopyrans - therapeutic use Clinical Trials as Topic Dementia Dementia - drug therapy Ensaculin Humans Memory Memory - drug effects Neuroprotection Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotransmitters NMDA antagonists Piperazines - pharmacokinetics Piperazines - pharmacology Piperazines - therapeutic use Receptors, Adrenergic, alpha-1 - drug effects Receptors, Dopamine D2 - drug effects Receptors, Dopamine D3 Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, Serotonin - drug effects Receptors, Serotonin, 5-HT1 Synaptic Transmission - drug effects
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!