Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesis

Cyclooxygenase (COX)‐2 and the prostaglandins resulting from its enzymatic activity have been shown to play a role in modulating cell growth and development of human neoplasia. Evidence includes a direct relationship between COX‐2 expression and cancer incidence in humans and animal models, increase...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2003-07, Vol.7 (3), p.207-222
Hauptverfasser:	Trifan, O. C., Hla, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animal models Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Antineoplastic Agents - metabolism Apoptosis Apoptosis - physiology Cell culture Cell Division - physiology Cell growth Cell Transformation, Neoplastic Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - metabolism Cyclooxygenase‐1 and‐2 Drug development Enzymatic activity Gene Expression Regulation, Enzymologic Humans Inflammation Isoenzymes - genetics Isoenzymes - metabolism Membrane Proteins Nonsteroidal anti-inflammatory drugs Nuclear receptors Peroxisome proliferator-activated receptors Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins Prostaglandins - metabolism Receptor mechanisms Receptors, Cytoplasmic and Nuclear - metabolism Review Transcription Factors - metabolism Tumorigenesis
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