Regulation of Natural Cell Death in Dopaminergic Neurons of the Substantia Nigra by Striatal Glial Cell Line-Derived Neurotrophic Factor In Vivo

Dopamine (DA) neurons of the substantia nigra undergo a developmental cell death event that is biphasic, with peaks just after birth and at postnatal day 14. As envisioned by neurotrophic theory, this cell death is likely to be regulated by target interactions because it is augmented by their disrup...

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Veröffentlicht in:	The Journal of neuroscience 2003-06, Vol.23 (12), p.5141-5148
Hauptverfasser:	Oo, Tinmarla Frances, Kholodilov, Nikolai, Burke, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibodies - administration & dosage Antibody Specificity Apoptosis - drug effects Apoptosis - physiology Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Development/Plasticity/Repair Dopamine - metabolism Drug Administration Routes Glial Cell Line-Derived Neurotrophic Factor Nerve Growth Factors - administration & dosage Nerve Growth Factors - antagonists & inhibitors Nerve Growth Factors - physiology Neurons - cytology Neurons - drug effects Neurons - physiology Rats Rats, Sprague-Dawley Substantia Nigra - cytology Substantia Nigra - physiology
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