Increased Susceptibility of Striatal Mitochondria to Calcium-Induced Permeability Transition

Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition. Striatal mitochondria showed an increased dose-dependent sensitivity to Ca2+ compared with cortical mitochond...

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Veröffentlicht in:	The Journal of neuroscience 2003-06, Vol.23 (12), p.4858-4867
Hauptverfasser:	Brustovetsky, Nickolay, Brustovetsky, Tatiana, Purl, Kevin J, Capano, Michela, Crompton, Martin, Dubinsky, Janet M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Animals Calcium - pharmacokinetics Calcium - pharmacology Cellular/Molecular Cerebral Cortex - chemistry Corpus Striatum - chemistry Cyclophilins - analysis Cyclophilins - metabolism Dose-Response Relationship, Drug Electron Transport - drug effects Electron Transport - physiology Enzyme Inhibitors - pharmacology Female Huntington Disease - etiology Huntington Disease - metabolism Light Male Membrane Potentials - drug effects Membrane Potentials - physiology Mitochondria - chemistry Mitochondria - drug effects Mitochondria - metabolism Peptidyl-Prolyl Isomerase F Permeability - drug effects Rats Reactive Oxygen Species - chemistry Scattering, Radiation
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