Neuroprotection by the Endogenous Cannabinoid Anandamide and Arvanil against In Vivo Excitotoxicity in the Rat: Role of Vanilloid Receptors and Lipoxygenases

Type 1 vanilloid receptors (VR1) have been identified recently in the brain, in which they serve as yet primarily undetermined purposes. The endocannabinoid anandamide (AEA) and some of its oxidative metabolites are ligands for VR1, and AEA has been shown to afford protection against ouabain-induced...

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Veröffentlicht in:	The Journal of neuroscience 2003-05, Vol.23 (10), p.4127-4133
Hauptverfasser:	Veldhuis, W. B, van der Stelt, M, Wadman, M. W, van Zadelhoff, G, Maccarrone, M, Fezza, F, Veldink, G. A, Vliegenthart, J. F. G, Bar, P. R, Nicolay, K, Marzo, V. Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Arachidonic Acids - physiology arvanil Blood Cells - drug effects Blood Cells - enzymology Blood Cells - metabolism Brain - drug effects Brain - enzymology Brain - metabolism Brain Chemistry Brain Mapping Cannabinoid Receptor Modulators Cannabinoids - pharmacology Capsaicin - analogs & derivatives Capsaicin - metabolism capsaicin receptors Cellular/Molecular Endocannabinoids Ethanolamines - analysis Ethanolamines - metabolism Fatty Acids, Unsaturated - physiology Lipoxygenase - metabolism Lipoxygenase - physiology Male Masoprocol - pharmacology Nerve Degeneration - chemically induced Nerve Degeneration - enzymology Nerve Degeneration - prevention & control Neuroprotective Agents - pharmacology Ouabain - pharmacology Polyunsaturated Alkamides Rats Rats, Wistar Receptors, Drug - metabolism Receptors, Drug - physiology
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