Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats
The role of the ventral subiculum in cocaine- or cue-induced cocaine-seeking behavior was investigated in rats tested on a between-session reinstatement model. Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding w...
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| Veröffentlicht in: | The Journal of neuroscience 2003-11, Vol.23 (32), p.10258-10264 |
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| creator | Sun, WenLin Rebec, George V |
| description | The role of the ventral subiculum in cocaine- or cue-induced cocaine-seeking behavior was investigated in rats tested on a between-session reinstatement model. Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding was reinforced contingent on a modified fixed-ratio 5 schedule. Reinstatement tests began after the lever-pressing behavior was extinguished in the absence of cocaine and conditioned cues (light and tone). Bilateral microinjections of lidocaine (100 microg) into the ventral subiculum decreased cocaine- or cue-induced reinstatement of cocaine-seeking behavior compared with saline microinjections into the same area in another group of rats. Lidocaine microinjections, however, had no effect on cocaine self-administration behavior or food-maintained or food-reinstated responding. Collectively, these results suggest that the ventral subiculum plays an important role in cocaine-seeking behavior. Considering the role of this structure in context learning, our data suggest that the full expression of cocaine- or cue-induced reinstatement may depend on the context in which the cocaine experience occurred. |
| doi_str_mv | 10.1523/jneurosci.23-32-10258.2003 |
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Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding was reinforced contingent on a modified fixed-ratio 5 schedule. Reinstatement tests began after the lever-pressing behavior was extinguished in the absence of cocaine and conditioned cues (light and tone). Bilateral microinjections of lidocaine (100 microg) into the ventral subiculum decreased cocaine- or cue-induced reinstatement of cocaine-seeking behavior compared with saline microinjections into the same area in another group of rats. Lidocaine microinjections, however, had no effect on cocaine self-administration behavior or food-maintained or food-reinstated responding. Collectively, these results suggest that the ventral subiculum plays an important role in cocaine-seeking behavior. Considering the role of this structure in context learning, our data suggest that the full expression of cocaine- or cue-induced reinstatement may depend on the context in which the cocaine experience occurred.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/jneurosci.23-32-10258.2003</identifier><identifier>PMID: 14614084</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Anesthetics, Local - pharmacology ; Animals ; Behavior, Animal - drug effects ; Behavioral/Systems/Cognitive ; Cocaine - pharmacology ; Cocaine-Related Disorders - drug therapy ; Cocaine-Related Disorders - physiopathology ; Conditioning, Operant - drug effects ; Cues ; Drug Antagonism ; drug-seeking behavior ; Extinction, Psychological - drug effects ; Feeding Behavior - drug effects ; Hippocampus - drug effects ; Hippocampus - physiopathology ; Lidocaine - pharmacology ; Male ; Microinjections ; Rats ; Rats, Sprague-Dawley ; Reinforcement (Psychology) ; Self Administration</subject><ispartof>The Journal of neuroscience, 2003-11, Vol.23 (32), p.10258-10264</ispartof><rights>Copyright © 2003 Society for Neuroscience 0270-6474/03/2310258-07.00/0 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-dd9040e274673b4bf58e681f1610ce71b98f608e32e4030c8c395c49746624d83</citedby><cites>FETCH-LOGICAL-c486t-dd9040e274673b4bf58e681f1610ce71b98f608e32e4030c8c395c49746624d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741020/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741020/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14614084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, WenLin</creatorcontrib><creatorcontrib>Rebec, George V</creatorcontrib><title>Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>The role of the ventral subiculum in cocaine- or cue-induced cocaine-seeking behavior was investigated in rats tested on a between-session reinstatement model. Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding was reinforced contingent on a modified fixed-ratio 5 schedule. Reinstatement tests began after the lever-pressing behavior was extinguished in the absence of cocaine and conditioned cues (light and tone). Bilateral microinjections of lidocaine (100 microg) into the ventral subiculum decreased cocaine- or cue-induced reinstatement of cocaine-seeking behavior compared with saline microinjections into the same area in another group of rats. Lidocaine microinjections, however, had no effect on cocaine self-administration behavior or food-maintained or food-reinstated responding. Collectively, these results suggest that the ventral subiculum plays an important role in cocaine-seeking behavior. Considering the role of this structure in context learning, our data suggest that the full expression of cocaine- or cue-induced reinstatement may depend on the context in which the cocaine experience occurred.</description><subject>Anesthetics, Local - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral/Systems/Cognitive</subject><subject>Cocaine - pharmacology</subject><subject>Cocaine-Related Disorders - drug therapy</subject><subject>Cocaine-Related Disorders - physiopathology</subject><subject>Conditioning, Operant - drug effects</subject><subject>Cues</subject><subject>Drug Antagonism</subject><subject>drug-seeking behavior</subject><subject>Extinction, Psychological - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiopathology</subject><subject>Lidocaine - pharmacology</subject><subject>Male</subject><subject>Microinjections</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reinforcement (Psychology)</subject><subject>Self Administration</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU-P0zAQxS0EYsvCV0AWB8QlZfynjsMBaakWKKpYacvC0XKcSeslsXfjpBXfnpRUsJxGo_m9N6N5hLxiMGcLLt7eBhy6mJyfc5EJnjHgCz3nAOIRmY1EkXEJ7DGZAc8hUzKXZ-RZSrcAkAPLn5IzJhWToOWM_Fj7KjrrA9JVsK73e9v7GGis6XcMfWcbuhlK74ZmaOlF32MYbI-JLidRtkH86cOWfsCd3fvYUR_ote3Tc_Kktk3CF6d6Tm4-Xn5bfs7WV59Wy4t15qRWfVZVBUhAnkuVi1KW9UKj0qxmioHDnJWFrhVoFBwlCHDaiWLhZDHyistKi3PyfvK9G8oWKzfdbO4639rul4nWm_8nwe_MNu6NyuX4NxgNXp8Mung_YOpN65PDprEB45AMK1ghlTxuejeBbvx96rD-u4SBOeZivny9vLm-2ixXZmwEN39yMcdcRvHLh2f-k56CGIE3E7Dz293Bd2hSa5tmxJk5HA4PDMVvJouaHA</recordid><startdate>20031112</startdate><enddate>20031112</enddate><creator>Sun, WenLin</creator><creator>Rebec, George V</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20031112</creationdate><title>Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats</title><author>Sun, WenLin ; Rebec, George V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-dd9040e274673b4bf58e681f1610ce71b98f608e32e4030c8c395c49746624d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anesthetics, Local - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral/Systems/Cognitive</topic><topic>Cocaine - pharmacology</topic><topic>Cocaine-Related Disorders - drug therapy</topic><topic>Cocaine-Related Disorders - physiopathology</topic><topic>Conditioning, Operant - drug effects</topic><topic>Cues</topic><topic>Drug Antagonism</topic><topic>drug-seeking behavior</topic><topic>Extinction, Psychological - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiopathology</topic><topic>Lidocaine - pharmacology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement (Psychology)</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, WenLin</creatorcontrib><creatorcontrib>Rebec, George V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, WenLin</au><au>Rebec, George V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2003-11-12</date><risdate>2003</risdate><volume>23</volume><issue>32</issue><spage>10258</spage><epage>10264</epage><pages>10258-10264</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>The role of the ventral subiculum in cocaine- or cue-induced cocaine-seeking behavior was investigated in rats tested on a between-session reinstatement model. Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding was reinforced contingent on a modified fixed-ratio 5 schedule. Reinstatement tests began after the lever-pressing behavior was extinguished in the absence of cocaine and conditioned cues (light and tone). Bilateral microinjections of lidocaine (100 microg) into the ventral subiculum decreased cocaine- or cue-induced reinstatement of cocaine-seeking behavior compared with saline microinjections into the same area in another group of rats. Lidocaine microinjections, however, had no effect on cocaine self-administration behavior or food-maintained or food-reinstated responding. Collectively, these results suggest that the ventral subiculum plays an important role in cocaine-seeking behavior. Considering the role of this structure in context learning, our data suggest that the full expression of cocaine- or cue-induced reinstatement may depend on the context in which the cocaine experience occurred.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>14614084</pmid><doi>10.1523/jneurosci.23-32-10258.2003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthetics, Local - pharmacology Animals Behavior, Animal - drug effects Behavioral/Systems/Cognitive Cocaine - pharmacology Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - physiopathology Conditioning, Operant - drug effects Cues Drug Antagonism drug-seeking behavior Extinction, Psychological - drug effects Feeding Behavior - drug effects Hippocampus - drug effects Hippocampus - physiopathology Lidocaine - pharmacology Male Microinjections Rats Rats, Sprague-Dawley Reinforcement (Psychology) Self Administration |
| title | Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats |
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