Sertoli‐Leydig cell tumor ‐ a rare androgen secreting ovarian tumor in postmenopausal women: case report and review of literature
Sertoli‐Leydig cell tumors (SLCT) constitute only 1‐0.5% of all primary ovarian neoplasms. We report a SLCT in a postmenopausal woman aged 69 years. The physical examination revealed severe hirsutism. Basal hormonal evaluation showed high plasma testosterone and estradiol values, with suppressed pla...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2003-10, Vol.7 (4), p.461-471 |
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| creator | Gheorghisan‐Galateanu, Ancuta Fica, Simona Terzea, Dana Cristina Caragheorgheopol, Andra Horhoianu, V. |
| description | Sertoli‐Leydig cell tumors (SLCT) constitute only 1‐0.5% of all primary ovarian neoplasms. We report a SLCT in a postmenopausal woman aged 69 years. The physical examination revealed severe hirsutism. Basal hormonal evaluation showed high plasma testosterone and estradiol values, with suppressed plasma gonadotropins. Computer tomograph scan revealed a right ovarian tumor mass of 4,3/3 cm, confirming an androgen secreting ovarian tumor. The histopathological and immunocytochemical examination established the diagnosis of well differentiated Sertoli‐Leydig cell tumor. The tumor was positive for cytokeratin KL 1 and S‐100 protein and, in isolated tumor cells, positive for alpha‐fetoprotein. Postsurgical evolution was favorable; controls after 6 months and 3,5 years showed marked reduction of hirsutism, normal plasma testosterone values and gonadotropins in normal postmenopausal range. We discuss the complex aspects of etiology and pathogenesis, the clinical and hormonal settings, the role of immunocytochemical markers in diagnosis, as well as the therapy and the prognostic features of this ovarian tumor. |
| doi_str_mv | 10.1111/j.1582-4934.2003.tb00249.x |
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We report a SLCT in a postmenopausal woman aged 69 years. The physical examination revealed severe hirsutism. Basal hormonal evaluation showed high plasma testosterone and estradiol values, with suppressed plasma gonadotropins. Computer tomograph scan revealed a right ovarian tumor mass of 4,3/3 cm, confirming an androgen secreting ovarian tumor. The histopathological and immunocytochemical examination established the diagnosis of well differentiated Sertoli‐Leydig cell tumor. The tumor was positive for cytokeratin KL 1 and S‐100 protein and, in isolated tumor cells, positive for alpha‐fetoprotein. Postsurgical evolution was favorable; controls after 6 months and 3,5 years showed marked reduction of hirsutism, normal plasma testosterone values and gonadotropins in normal postmenopausal range. We discuss the complex aspects of etiology and pathogenesis, the clinical and hormonal settings, the role of immunocytochemical markers in diagnosis, as well as the therapy and the prognostic features of this ovarian tumor.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/j.1582-4934.2003.tb00249.x</identifier><identifier>PMID: 14754515</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>17β-Estradiol ; Aged ; androgen secreting ovarian tumor ; Androgens ; Androgens - metabolism ; Cell differentiation ; Cytokeratin ; Diagnosis ; Female ; Gonadotropins ; Hirsutism ; Humans ; Miracles ; Ovarian cancer ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - metabolism ; Ovaries ; pathogenesis ; Pituitary (anterior) ; Post-menopause ; postmenpause ; S100 protein ; Sertoli-Leydig Cell Tumor - diagnosis ; Sertoli-Leydig Cell Tumor - metabolism ; Sertoli‐Leydig cell tumor ; Testosterone ; Tumor cells ; Tumors ; α-Fetoprotein</subject><ispartof>Journal of cellular and molecular medicine, 2003-10, Vol.7 (4), p.461-471</ispartof><rights>2003. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). 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We report a SLCT in a postmenopausal woman aged 69 years. The physical examination revealed severe hirsutism. Basal hormonal evaluation showed high plasma testosterone and estradiol values, with suppressed plasma gonadotropins. Computer tomograph scan revealed a right ovarian tumor mass of 4,3/3 cm, confirming an androgen secreting ovarian tumor. The histopathological and immunocytochemical examination established the diagnosis of well differentiated Sertoli‐Leydig cell tumor. The tumor was positive for cytokeratin KL 1 and S‐100 protein and, in isolated tumor cells, positive for alpha‐fetoprotein. Postsurgical evolution was favorable; controls after 6 months and 3,5 years showed marked reduction of hirsutism, normal plasma testosterone values and gonadotropins in normal postmenopausal range. We discuss the complex aspects of etiology and pathogenesis, the clinical and hormonal settings, the role of immunocytochemical markers in diagnosis, as well as the therapy and the prognostic features of this ovarian tumor.</description><subject>17β-Estradiol</subject><subject>Aged</subject><subject>androgen secreting ovarian tumor</subject><subject>Androgens</subject><subject>Androgens - metabolism</subject><subject>Cell differentiation</subject><subject>Cytokeratin</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Gonadotropins</subject><subject>Hirsutism</subject><subject>Humans</subject><subject>Miracles</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovaries</subject><subject>pathogenesis</subject><subject>Pituitary (anterior)</subject><subject>Post-menopause</subject><subject>postmenpause</subject><subject>S100 protein</subject><subject>Sertoli-Leydig Cell Tumor - diagnosis</subject><subject>Sertoli-Leydig Cell Tumor - metabolism</subject><subject>Sertoli‐Leydig cell tumor</subject><subject>Testosterone</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>α-Fetoprotein</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkk2v1CAUhhuj8V6v_gVDNHE3FVpo4S40ZuJn5saFuiaUno5MWqhAZ-7s3Lj3N_pLpE5z_djJ5hw4z3nD4SXLHhGck7Se7nLCeLGioqR5gXGZxwbjgor8-lZ2flO6veSEl_wsuxfCLqEVKcXd7IzQmlFG2Hn27QP46Hrz4-v3DRxbs0Ua-h7FaXAepUOkkFcekLKtd1uwKID2EI3dIrdX3ii7sMai0YU4gHWjmoLq0cGlzSXSKgDyMDofZ5WU7g0ckOtQbyJ4FScP97M7neoDPFjiRfbp1cuP6zerzfvXb9cvNivNcEVWlCmthK5YU6VIQTSEc9U0mvKSqE51tK20FpVuha5bVVWcY1YIUugWSmC4vMienXTHqRmg1WCjV70cvRmUP0qnjPy7Ys1nuXV7WdUUY06TwJNFwLsvE4QoBxPmF1MW3BRkTRipBS8S-PgfcOcmb9NwssR1en7Bf8ldnijtXQgeupurECxnr-VOzibK2VA5ey0Xr-V1an745zC_WxdzE_D8BBxMD8f_kJbv1ldXNP2Vn66sv94</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Gheorghisan‐Galateanu, Ancuta</creator><creator>Fica, Simona</creator><creator>Terzea, Dana Cristina</creator><creator>Caragheorgheopol, Andra</creator><creator>Horhoianu, V.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200310</creationdate><title>Sertoli‐Leydig cell tumor ‐ a rare androgen secreting ovarian tumor in postmenopausal women: case report and review of literature</title><author>Gheorghisan‐Galateanu, Ancuta ; Fica, Simona ; Terzea, Dana Cristina ; Caragheorgheopol, Andra ; Horhoianu, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5061-45aca9c65b6ca94e9b188abbc4831afaf4d6cc96cd9c7da6688052912cde3e503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>17β-Estradiol</topic><topic>Aged</topic><topic>androgen secreting ovarian tumor</topic><topic>Androgens</topic><topic>Androgens - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Gheorghisan‐Galateanu, Ancuta</au><au>Fica, Simona</au><au>Terzea, Dana Cristina</au><au>Caragheorgheopol, Andra</au><au>Horhoianu, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sertoli‐Leydig cell tumor ‐ a rare androgen secreting ovarian tumor in postmenopausal women: case report and review of literature</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2003-10</date><risdate>2003</risdate><volume>7</volume><issue>4</issue><spage>461</spage><epage>471</epage><pages>461-471</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Sertoli‐Leydig cell tumors (SLCT) constitute only 1‐0.5% of all primary ovarian neoplasms. We report a SLCT in a postmenopausal woman aged 69 years. The physical examination revealed severe hirsutism. Basal hormonal evaluation showed high plasma testosterone and estradiol values, with suppressed plasma gonadotropins. Computer tomograph scan revealed a right ovarian tumor mass of 4,3/3 cm, confirming an androgen secreting ovarian tumor. The histopathological and immunocytochemical examination established the diagnosis of well differentiated Sertoli‐Leydig cell tumor. The tumor was positive for cytokeratin KL 1 and S‐100 protein and, in isolated tumor cells, positive for alpha‐fetoprotein. Postsurgical evolution was favorable; controls after 6 months and 3,5 years showed marked reduction of hirsutism, normal plasma testosterone values and gonadotropins in normal postmenopausal range. We discuss the complex aspects of etiology and pathogenesis, the clinical and hormonal settings, the role of immunocytochemical markers in diagnosis, as well as the therapy and the prognostic features of this ovarian tumor.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14754515</pmid><doi>10.1111/j.1582-4934.2003.tb00249.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 17β-Estradiol Aged androgen secreting ovarian tumor Androgens Androgens - metabolism Cell differentiation Cytokeratin Diagnosis Female Gonadotropins Hirsutism Humans Miracles Ovarian cancer Ovarian Neoplasms - diagnosis Ovarian Neoplasms - metabolism Ovaries pathogenesis Pituitary (anterior) Post-menopause postmenpause S100 protein Sertoli-Leydig Cell Tumor - diagnosis Sertoli-Leydig Cell Tumor - metabolism Sertoli‐Leydig cell tumor Testosterone Tumor cells Tumors α-Fetoprotein |
| title | Sertoli‐Leydig cell tumor ‐ a rare androgen secreting ovarian tumor in postmenopausal women: case report and review of literature |
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