The anaphase-promoting complex/cyclosome: a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma

Background The aggressive B-cell non-Hodgkin lymphomas diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) are characterised by a high proliferation rate. The anaphase-promoting complex/cyclosome (APC/C) and its co-activators Cdc20 and Cdh1 represent an important checkpoint in mitos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2019-06, Vol.120 (12), p.1137-1146
Hauptverfasser:	Maes, Anke, Maes, Ken, De Raeve, Hendrik, De Smedt, Eva, Vlummens, Philip, Szablewski, Vanessa, Devin, Julie, Faict, Sylvia, De Veirman, Kim, Menu, Eline, Offner, Fritz, Spaargaren, Marcel, Moreaux, Jérôme, Vanderkerken, Karin, Van Valckenborgh, Els, De Bruyne, Elke
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/291/1621/1915 631/80/641/1655 Anaphase Anaphase-promoting complex Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors Anaphase-Promoting Complex-Cyclosome - metabolism Antigens, CD - biosynthesis Antigens, CD - genetics Apoptosis Apoptosis - drug effects B-cell lymphoma Bcl-2 protein Bcl-x protein Biomedical and Life Sciences Biomedicine Cadherins - biosynthesis Cadherins - genetics Cancer Research Caspase Cdc20 Proteins - biosynthesis Cdc20 Proteins - genetics Cell Line, Tumor Cyclin B1 Doxorubicin Drug Resistance E-cadherin Epidemiology Gene Expression Profiling Humans Immunohistochemistry Inactivation Life Sciences Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Mantle-Cell - drug therapy Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Mantle cell lymphoma Metaphase Mitosis Molecular Medicine Molecular Targeted Therapy Oncology Prodrugs - pharmacology Prognosis RNA, Messenger - biosynthesis RNA, Messenger - genetics Tosylarginine Methyl Ester - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!