A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide

The RARG gene is a member of the nuclear hormone receptor superfamily and shares high homology with RARA and RARB . RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL). Little is known about RARB or RARG rearrangement. RARG fusions were reported in only five APL patient...

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Veröffentlicht in:	British journal of cancer 2019-05, Vol.120 (11), p.1023-1025
Hauptverfasser:	Chen, Xue, Wang, Fang, Zhang, Yang, Teng, Wen, Cao, Panxiang, Ma, Xiaoli, Liu, Mingyue, Tian, Yaoyao, Wang, Tong, Nie, Daijing, Zhang, Jing, Liu, Hongxing, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/1897 692/4017 692/4028/67/1990/283/1897 Acid resistance Acute myeloid leukemia Aged Arsenic Arsenic trioxide Arsenic Trioxide - therapeutic use Biomedical and Life Sciences Biomedicine Brief Communication Cancer Research Drug Resistance Drug Resistance, Neoplasm Epidemiology Gene Fusion Homology Humans Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Promyelocytic, Acute - genetics Male Molecular Medicine Nuclear Proteins - genetics Nucleophosmin Oncology Receptors, Retinoic Acid - genetics Retinoic acid Retinoic Acid Receptor gamma Retinoic acid receptors Transcription Translocation Tretinoin Tretinoin - therapeutic use
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