Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy

Summary The human‐adapted pathogen group A Streptococcus (GAS) utilizes wounds as portals of entry into host tissue, wherein surface adhesins interact with the extracellular matrix, enabling bacterial colonization. The streptococcal collagen‐like protein 1 (Scl1) is a major adhesin of GAS that selec...

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Veröffentlicht in:	Molecular microbiology 2019-09, Vol.112 (3), p.800-819
Hauptverfasser:	McNitt, Dudley H., Choi, Soo Jeon, Allen, Jessica L., Hames, River A., Weed, Scott A., Van De Water, Livingston, Berisio, Rita, Lukomski, Slawomir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adhesins Adhesins, Bacterial - chemistry Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Alternative splicing Bacterial Adhesion Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Biofilms Biomedical materials Cancer Cancer therapies Cell Line, Tumor Collagen Collagen - chemistry Collagen - genetics Collagen - metabolism Colonization Domains Extracellular matrix Extracellular Matrix - metabolism Fibroblasts Fibroblasts - metabolism Fibroblasts - microbiology Fibronectin Fibronectins - chemistry Fibronectins - genetics Fibronectins - metabolism Humans Isoforms Neoplasms - metabolism Neoplasms - therapy Osteosarcoma Osteosarcoma cells Protein Binding Protein Domains Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Streptococcus Streptococcus infections Streptococcus pyogenes - chemistry Streptococcus pyogenes - genetics Streptococcus pyogenes - physiology Tenascin Tumors Wounds
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