A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

Background Combined focal adhesion kinase (FAK) and MEK inhibition may provide greater anticancer effect than FAK monotherapy. Methods This dose-finding phase Ib study (adaptive 3 + 3 design) determined the maximum tolerated dose (MTD) of trametinib and the FAK inhibitor GSK2256098 in combination. E...

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Veröffentlicht in:	British journal of cancer 2019-05, Vol.120 (10), p.975-981
Hauptverfasser:	Mak, Gabriel, Soria, Jean-Charles, Blagden, Sarah P., Plummer, Ruth, Fleming, Ronald A., Nebot, Noelia, Zhang, Jianping, Mazumdar, Jolly, Rogan, Debra, Gazzah, Anas, Rizzuto, Ivana, Greystoke, Alastair, Yan, Li, Tolson, Jerry, Auger, Kurt R., Arkenau, Hendrik-Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028 692/4028/67/1641 Adhesion Aged Aminopyridines - administration & dosage Aminopyridines - adverse effects Aminopyridines - pharmacokinetics Appetite loss Biomedical and Life Sciences Biomedicine Cancer Research Diarrhea Dose-Response Relationship, Drug Drug Resistance Drug-Related Side Effects and Adverse Reactions - classification Drug-Related Side Effects and Adverse Reactions - pathology Enzyme inhibitors Epidemiology Exposure Female Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - genetics Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - adverse effects Hydroxamic Acids - pharmacokinetics Inhibitor drugs Kinases Male Mesothelioma Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma - pathology Middle Aged Molecular Medicine Nausea Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Oncology Pharmacodynamics Pharmacokinetics Progression-Free Survival Protein kinase Pruritus Pyridones - administration & dosage Pyridones - adverse effects Pyridones - pharmacokinetics Pyrimidinones - administration & dosage Pyrimidinones - adverse effects Pyrimidinones - pharmacokinetics Solid tumors Targeted cancer therapy Toxicity Tumors
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