Pregnancy outcomes among women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion versus multiple daily injections: A retrospective cohort study
Background Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in women with type 1 diabetes mellitus using continuous subcutaneous insulin i...
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| Veröffentlicht in: | Obstetric medicine 2019-09, Vol.12 (3), p.136-142 |
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| creator | Dixon, Benjamin RS Nankervis, Alison Hopkins, Stephanie CN Cade, Thomas J |
| description | Background
Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion or multiple daily injections in pregnancy.
Methods
Retrospective single-centre cohort study of 298 pregnancies booked between 2006 and 2016. Descriptive analysis was performed for HbA1c values. Logistic regression models were created to compare selected maternal and neonatal outcomes.
Results
Continuous subcutaneous insulin infusion was associated with increased risk of large-for-gestational age (aOR 2.00, 95% CI 1.20–3.34) and preterm neonates (aOR 1.80, 95% CI 1.04–3.03). Continuous subcutaneous insulin infusion had no association with increased risk of adverse pregnancy outcomes. No difference in HbA1c values existed between groups.
Conclusion
Using continuous subcutaneous insulin infusion for type 1 diabetes mellitus through pregnancy is associated with increased risk of large-for-gestational age and preterm neonates, without increased risk of associated adverse maternal or neonatal outcomes. |
| doi_str_mv | 10.1177/1753495X18797769 |
| format | Article |
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Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion or multiple daily injections in pregnancy.
Methods
Retrospective single-centre cohort study of 298 pregnancies booked between 2006 and 2016. Descriptive analysis was performed for HbA1c values. Logistic regression models were created to compare selected maternal and neonatal outcomes.
Results
Continuous subcutaneous insulin infusion was associated with increased risk of large-for-gestational age (aOR 2.00, 95% CI 1.20–3.34) and preterm neonates (aOR 1.80, 95% CI 1.04–3.03). Continuous subcutaneous insulin infusion had no association with increased risk of adverse pregnancy outcomes. No difference in HbA1c values existed between groups.
Conclusion
Using continuous subcutaneous insulin infusion for type 1 diabetes mellitus through pregnancy is associated with increased risk of large-for-gestational age and preterm neonates, without increased risk of associated adverse maternal or neonatal outcomes.</description><identifier>ISSN: 1753-495X</identifier><identifier>EISSN: 1753-4968</identifier><identifier>DOI: 10.1177/1753495X18797769</identifier><identifier>PMID: 31523270</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Cohort analysis ; Diabetes ; Glucose ; Health risk assessment ; Insulin ; Newborn babies ; Original ; Pregnancy ; Womens health</subject><ispartof>Obstetric medicine, 2019-09, Vol.12 (3), p.136-142</ispartof><rights>The Author(s) 2018</rights><rights>The Author(s) 2018 2018 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c415t-edd2397738fd50984580c2ea54d602baa84c41b9476828b6353b57fe56cce5753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734631/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734631/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21798,27901,27902,43597,43598,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31523270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dixon, Benjamin RS</creatorcontrib><creatorcontrib>Nankervis, Alison</creatorcontrib><creatorcontrib>Hopkins, Stephanie CN</creatorcontrib><creatorcontrib>Cade, Thomas J</creatorcontrib><title>Pregnancy outcomes among women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion versus multiple daily injections: A retrospective cohort study</title><title>Obstetric medicine</title><addtitle>Obstet Med</addtitle><description>Background
Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion or multiple daily injections in pregnancy.
Methods
Retrospective single-centre cohort study of 298 pregnancies booked between 2006 and 2016. Descriptive analysis was performed for HbA1c values. Logistic regression models were created to compare selected maternal and neonatal outcomes.
Results
Continuous subcutaneous insulin infusion was associated with increased risk of large-for-gestational age (aOR 2.00, 95% CI 1.20–3.34) and preterm neonates (aOR 1.80, 95% CI 1.04–3.03). Continuous subcutaneous insulin infusion had no association with increased risk of adverse pregnancy outcomes. No difference in HbA1c values existed between groups.
Conclusion
Using continuous subcutaneous insulin infusion for type 1 diabetes mellitus through pregnancy is associated with increased risk of large-for-gestational age and preterm neonates, without increased risk of associated adverse maternal or neonatal outcomes.</description><subject>Cohort analysis</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Insulin</subject><subject>Newborn babies</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Womens health</subject><issn>1753-495X</issn><issn>1753-4968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kk1v1DAQhiMEoqVw54QsceES8EccJxyQqoovqRIcQOotcpzJrleJvfhjq_wlfiUTbVmgEqcZzzx-7XntonjO6GvGlHrDlBRVK29Yo1ql6vZBcb6Wyqqtm4enXN6cFU9i3FFaS8HF4-JMMMkFV_S8-Pk1wMZpZxbiczJ-hkj07N2G3GLuyK1NW5KWPRBGBqt7SAjMME025UhytEga75J12WMh5t7kpB2sC-tinqzDOCLoHTlAiFif85TsfgIyaDst2N6BSdiPb8klCZCCj_u1cgCU3vqQSEx5WJ4Wj0Y9RXh2Fy-K7x_ef7v6VF5_-fj56vK6NBWTqYRh4ALdEM04SNo2lWyo4aBlNdSU91o3FYJ9W6m64U1fCyl6qUaQtTEg0bGL4t1Rd5_7GQYDLgU9dftgZx2Wzmvb_dtxdttt_KGrlahqwVDg1Z1A8D8yxNTNNhr07OhLx3lLWykEqxB9eQ_d-RwcjrdSbVVTxVuk6JEyaE0MMJ4uw2i3foTu_kfALS_-HuK04ffLI1Aegag38OfU_wr-AvrewU0</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Dixon, Benjamin RS</creator><creator>Nankervis, Alison</creator><creator>Hopkins, Stephanie CN</creator><creator>Cade, Thomas J</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Pregnancy outcomes among women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion versus multiple daily injections: A retrospective cohort study</title><author>Dixon, Benjamin RS ; Nankervis, Alison ; Hopkins, Stephanie CN ; Cade, Thomas J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-edd2397738fd50984580c2ea54d602baa84c41b9476828b6353b57fe56cce5753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cohort analysis</topic><topic>Diabetes</topic><topic>Glucose</topic><topic>Health risk assessment</topic><topic>Insulin</topic><topic>Newborn babies</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dixon, Benjamin RS</creatorcontrib><creatorcontrib>Nankervis, Alison</creatorcontrib><creatorcontrib>Hopkins, Stephanie CN</creatorcontrib><creatorcontrib>Cade, Thomas J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obstetric medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dixon, Benjamin RS</au><au>Nankervis, Alison</au><au>Hopkins, Stephanie CN</au><au>Cade, Thomas J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy outcomes among women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion versus multiple daily injections: A retrospective cohort study</atitle><jtitle>Obstetric medicine</jtitle><addtitle>Obstet Med</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>12</volume><issue>3</issue><spage>136</spage><epage>142</epage><pages>136-142</pages><issn>1753-495X</issn><eissn>1753-4968</eissn><abstract>Background
Insulin delivery options for pregnant women with type 1 diabetes mellitus are either continuous subcutaneous insulin infusion or multiple daily injections. The aim of this paper is to compare pregnancy outcomes in women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion or multiple daily injections in pregnancy.
Methods
Retrospective single-centre cohort study of 298 pregnancies booked between 2006 and 2016. Descriptive analysis was performed for HbA1c values. Logistic regression models were created to compare selected maternal and neonatal outcomes.
Results
Continuous subcutaneous insulin infusion was associated with increased risk of large-for-gestational age (aOR 2.00, 95% CI 1.20–3.34) and preterm neonates (aOR 1.80, 95% CI 1.04–3.03). Continuous subcutaneous insulin infusion had no association with increased risk of adverse pregnancy outcomes. No difference in HbA1c values existed between groups.
Conclusion
Using continuous subcutaneous insulin infusion for type 1 diabetes mellitus through pregnancy is associated with increased risk of large-for-gestational age and preterm neonates, without increased risk of associated adverse maternal or neonatal outcomes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31523270</pmid><doi>10.1177/1753495X18797769</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obstetric medicine, 2019-09, Vol.12 (3), p.136-142 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete; PubMed Central |
| subjects | Cohort analysis Diabetes Glucose Health risk assessment Insulin Newborn babies Original Pregnancy Womens health |
| title | Pregnancy outcomes among women with type 1 diabetes mellitus using continuous subcutaneous insulin infusion versus multiple daily injections: A retrospective cohort study |
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