Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges

•Background of lentiviral and adeno-associated virus vector design.•Reviewing of literature that reported in vivo microglial transduction.•Challenges to overcome low microglial transduction efficiency and specificity.•Guidelines for reporting viral transduction in microglia. Microglia have emerged a...

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Veröffentlicht in:	Neuroscience letters 2019-08, Vol.707, p.134310-134310, Article 134310
Hauptverfasser:	Maes, Margaret E., Colombo, Gloria, Schulz, Rouven, Siegert, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus (AAV) Animals Brain Dependovirus - genetics Gene Targeting Genetic Vectors HIV-1 - genetics Humans In-vivo transduction Lentivirus Lentivirus - genetics Microglia Microglia - metabolism Transduction, Genetic
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