Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor bio...
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| Veröffentlicht in: | BioMed research international 2019, Vol.2019 (2019), p.1-9 |
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| creator | You, Chong-Ge Yang, Wan-Xia Feng, Xiao-Fei Ma, Yao |
| description | Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm. |
| doi_str_mv | 10.1155/2019/1093815 |
| format | Article |
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New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/1093815</identifier><identifier>PMID: 31534952</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Biomarkers ; Biomarkers, Tumor - genetics ; Bladder ; Bladder cancer ; Cancer ; Cancer therapies ; Care and treatment ; Chemotherapy ; Cytokines ; Development and progression ; Drug dosages ; Female ; Gene expression ; Genes ; Genetic aspects ; Genomes ; Genomics ; Health aspects ; High-Throughput Nucleotide Sequencing ; Humans ; Immune system ; Immunology ; Immunotherapy ; Male ; Medical prognosis ; Medical research ; Melanoma ; Metastasis ; Mutation ; Next-generation sequencing ; Ontology ; Prognosis ; Therapeutic applications ; Tumor Microenvironment - genetics ; Tumorigenesis ; Tumors ; Urinary bladder ; Urinary Bladder Neoplasms - genetics</subject><ispartof>BioMed research international, 2019, Vol.2019 (2019), p.1-9</ispartof><rights>Copyright © 2019 Yao Ma et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Yao Ma et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Yao Ma et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-a933075b6318ae27b41725ed76389acf4844fb2e313c8ae449bcfb1d2c23262f3</citedby><cites>FETCH-LOGICAL-c499t-a933075b6318ae27b41725ed76389acf4844fb2e313c8ae449bcfb1d2c23262f3</cites><orcidid>0000-0002-3671-596X ; 0000-0003-1799-5502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732589/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732589/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,4028,27932,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31534952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chentoufi, Aziz A.</contributor><contributor>Aziz A Chentoufi</contributor><creatorcontrib>You, Chong-Ge</creatorcontrib><creatorcontrib>Yang, Wan-Xia</creatorcontrib><creatorcontrib>Feng, Xiao-Fei</creatorcontrib><creatorcontrib>Ma, Yao</creatorcontrib><title>Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm.</description><subject>Analysis</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Next-generation sequencing</subject><subject>Ontology</subject><subject>Prognosis</subject><subject>Therapeutic applications</subject><subject>Tumor Microenvironment - 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New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. 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| subjects | Analysis Biomarkers Biomarkers, Tumor - genetics Bladder Bladder cancer Cancer Cancer therapies Care and treatment Chemotherapy Cytokines Development and progression Drug dosages Female Gene expression Genes Genetic aspects Genomes Genomics Health aspects High-Throughput Nucleotide Sequencing Humans Immune system Immunology Immunotherapy Male Medical prognosis Medical research Melanoma Metastasis Mutation Next-generation sequencing Ontology Prognosis Therapeutic applications Tumor Microenvironment - genetics Tumorigenesis Tumors Urinary bladder Urinary Bladder Neoplasms - genetics |
| title | Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis |
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