Coding-complete sequence of a vaccine-derived recombinant porcine reproductive and respiratory syndrome virus strain isolated in Hungary
Porcine reproductive and respiratory syndrome virus 1 is a major cause of swine morbidity and mortality in various parts of the world, including Hungary. A national elimination programme to reduce the associated economic burden was initiated in Hungary in 2012. Using extensive laboratory surveillanc...
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| Veröffentlicht in: | Archives of virology 2019-10, Vol.164 (10), p.2605-2608 |
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| creator | Marton, S. Szalay, D. Kecskeméti, S. Forró, B. Olasz, F. Zádori, Z. Szabó, I. Molnár, T. Bányai, K. Bálint, Á. |
| description | Porcine reproductive and respiratory syndrome virus 1 is a major cause of swine morbidity and mortality in various parts of the world, including Hungary. A national elimination programme to reduce the associated economic burden was initiated in Hungary in 2012. Using extensive laboratory surveillance, we identified and isolated an unusual PRRSV strain. The complete coding sequence of this isolate was determined and analyzed. The genome of this Hungarian PRRSV1 strain, HUN60077/16, is 15,081 nucleotides in length. Phylogenetic and recombination analysis showed a mosaic structure of the genome where a large fragment of ORF1b and the genomic region coding for ORF3 to ORF7 showed a very close genetic relationship to the vaccine virus Unistrain, while the ORF1a region, the 3’ end of ORF1b, and the whole ORF2 were only distantly related to this or any other PRRSV1 strain whose genome sequence is available in the GenBank database. Genomic characterization of PRRSV strains is crucial when possible vaccine-associated cases are identified. This approach not only helps to identify genetic interactions between vaccine and wild-type PRRSV1 strains but may also be needed to prevent trust in commercial vaccines from being undermined. |
| doi_str_mv | 10.1007/s00705-019-04338-2 |
| format | Article |
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A national elimination programme to reduce the associated economic burden was initiated in Hungary in 2012. Using extensive laboratory surveillance, we identified and isolated an unusual PRRSV strain. The complete coding sequence of this isolate was determined and analyzed. The genome of this Hungarian PRRSV1 strain, HUN60077/16, is 15,081 nucleotides in length. Phylogenetic and recombination analysis showed a mosaic structure of the genome where a large fragment of ORF1b and the genomic region coding for ORF3 to ORF7 showed a very close genetic relationship to the vaccine virus Unistrain, while the ORF1a region, the 3’ end of ORF1b, and the whole ORF2 were only distantly related to this or any other PRRSV1 strain whose genome sequence is available in the GenBank database. Genomic characterization of PRRSV strains is crucial when possible vaccine-associated cases are identified. This approach not only helps to identify genetic interactions between vaccine and wild-type PRRSV1 strains but may also be needed to prevent trust in commercial vaccines from being undermined.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-019-04338-2</identifier><identifier>PMID: 31300889</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Annotated Sequence Record ; Biomedical and Life Sciences ; Biomedicine ; Genetic relationship ; Genomes ; Infectious Diseases ; Medical Microbiology ; Morbidity ; Nucleotide sequence ; Nucleotides ; Phylogeny ; Recombination ; Strains (organisms) ; Vaccines ; Virology</subject><ispartof>Archives of virology, 2019-10, Vol.164 (10), p.2605-2608</ispartof><rights>The Author(s) 2019</rights><rights>Archives of Virology is a copyright of Springer, (2019). All Rights Reserved. © 2019. 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A national elimination programme to reduce the associated economic burden was initiated in Hungary in 2012. Using extensive laboratory surveillance, we identified and isolated an unusual PRRSV strain. The complete coding sequence of this isolate was determined and analyzed. The genome of this Hungarian PRRSV1 strain, HUN60077/16, is 15,081 nucleotides in length. Phylogenetic and recombination analysis showed a mosaic structure of the genome where a large fragment of ORF1b and the genomic region coding for ORF3 to ORF7 showed a very close genetic relationship to the vaccine virus Unistrain, while the ORF1a region, the 3’ end of ORF1b, and the whole ORF2 were only distantly related to this or any other PRRSV1 strain whose genome sequence is available in the GenBank database. Genomic characterization of PRRSV strains is crucial when possible vaccine-associated cases are identified. This approach not only helps to identify genetic interactions between vaccine and wild-type PRRSV1 strains but may also be needed to prevent trust in commercial vaccines from being undermined.</description><subject>Annotated Sequence Record</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Genetic relationship</subject><subject>Genomes</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Morbidity</subject><subject>Nucleotide sequence</subject><subject>Nucleotides</subject><subject>Phylogeny</subject><subject>Recombination</subject><subject>Strains (organisms)</subject><subject>Vaccines</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcuO1DAQRS0EYpqBH2CBLLFhY_AzsTdIqAUM0khsYG05TqXxKLGDnbTUfzCfjUMPw2PBxraqTl1X1UXoOaOvGaXtm1IPqghlhlAphCb8AdoxKTjRrdEP0Y4KKoluqL5AT0q5obQGhHqMLgQTlGptduh2n_oQD8SnaR5hAVzg-wrRA04DdvjovA8RSA85HKHHGSrYhejigueUt1yNzTn1q18qgV3coDKH7JaUT7icYp_TBPgY8lpwWbILEYeSRrdUvfq-WuPB5dNT9GhwY4Fnd_cl-vrh_Zf9Fbn-_PHT_t018bKVCxk6aszQCdMZwzrpuVPayJ6BG1rPhAYjfN93ndHMaO1aNQxGNbyDQSohtRKX6O1Zd167CXoPsbY02jmHqXZhkwv270wM3-whHW3TCs4UrQKv7gRyqqsqi51C8TCOLkJai-VctW3drtQVffkPepPWHOt4G9WIRii-UfxM-ZxKyTDcN8Oo3Yy2Z6NtNdr-NNryWvTizzHuS345WwFxBkpNxQPk33__R_YH-Du4Eg</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Marton, S.</creator><creator>Szalay, D.</creator><creator>Kecskeméti, S.</creator><creator>Forró, B.</creator><creator>Olasz, F.</creator><creator>Zádori, Z.</creator><creator>Szabó, I.</creator><creator>Molnár, T.</creator><creator>Bányai, K.</creator><creator>Bálint, Á.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6270-1772</orcidid></search><sort><creationdate>20191001</creationdate><title>Coding-complete sequence of a vaccine-derived recombinant porcine reproductive and respiratory syndrome virus strain isolated in Hungary</title><author>Marton, S. ; 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A national elimination programme to reduce the associated economic burden was initiated in Hungary in 2012. Using extensive laboratory surveillance, we identified and isolated an unusual PRRSV strain. The complete coding sequence of this isolate was determined and analyzed. The genome of this Hungarian PRRSV1 strain, HUN60077/16, is 15,081 nucleotides in length. Phylogenetic and recombination analysis showed a mosaic structure of the genome where a large fragment of ORF1b and the genomic region coding for ORF3 to ORF7 showed a very close genetic relationship to the vaccine virus Unistrain, while the ORF1a region, the 3’ end of ORF1b, and the whole ORF2 were only distantly related to this or any other PRRSV1 strain whose genome sequence is available in the GenBank database. Genomic characterization of PRRSV strains is crucial when possible vaccine-associated cases are identified. 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| subjects | Annotated Sequence Record Biomedical and Life Sciences Biomedicine Genetic relationship Genomes Infectious Diseases Medical Microbiology Morbidity Nucleotide sequence Nucleotides Phylogeny Recombination Strains (organisms) Vaccines Virology |
| title | Coding-complete sequence of a vaccine-derived recombinant porcine reproductive and respiratory syndrome virus strain isolated in Hungary |
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