Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project
Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological cor...
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| creator | Rivera Bonet, Charlene N. Hermann, Bruce Cook, Cole J. Hwang, Gyujoon Dabbs, Kevin Nair, Veena Forseth, Courtney Mathis, Jedidiah Allen, Linda Almane, Dace N. Arkush, Karina Birn, Rasmus Conant, Lisa L. DeYoe, Edgar A. Felton, Elizabeth Humphries, Colin J. Kraegel, Peter Maganti, Rama Nencka, Andrew Nwoke, Onyekachi Raghavan, Manoj Rozman, Megan Shah, Umang Sosa, Veronica N. Struck, Aaron F. Tellapragada, Neelima Ustine, Candida Ward, B. Douglas Prabhakaran, Vivek Binder, Jeffrey R. Meyerand, Mary E. |
| description | Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
•Individuals with Temporal Lobe Epilepsy (TLE) show higher levels of neuroticism in the NEO-Five Factor Inventory.•Higher neuroticism is associated with earlier age of epilepsy onset.•Distributed reductions in cortical gray matter volumes were associated with increased neuroticism in TLE.•Hippocampal and amygdala volume were negatively associated with neuroticism in TLE. |
| doi_str_mv | 10.1016/j.yebeh.2019.07.025 |
| format | Article |
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•Individuals with Temporal Lobe Epilepsy (TLE) show higher levels of neuroticism in the NEO-Five Factor Inventory.•Higher neuroticism is associated with earlier age of epilepsy onset.•Distributed reductions in cortical gray matter volumes were associated with increased neuroticism in TLE.•Hippocampal and amygdala volume were negatively associated with neuroticism in TLE.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2019.07.025</identifier><identifier>PMID: 31387000</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Amygdala - diagnostic imaging ; Amygdala - physiology ; Big 5 traits ; Brain - diagnostic imaging ; Brain - physiology ; Connectome - methods ; Epilepsy, Temporal Lobe - diagnostic imaging ; Epilepsy, Temporal Lobe - psychology ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - physiology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; NEO-Five Factor Inventory ; Neuroticism - physiology ; Personality ; Personality - physiology ; Personality Inventory ; Temporal lobe epilepsy</subject><ispartof>Epilepsy & behavior, 2019-09, Vol.98 (Pt A), p.220-227</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-ade94f75e43258005892fb4699866e960caaf539081753d5d666bcef164bbb7b3</citedby><cites>FETCH-LOGICAL-c459t-ade94f75e43258005892fb4699866e960caaf539081753d5d666bcef164bbb7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525505019302100$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31387000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivera Bonet, Charlene N.</creatorcontrib><creatorcontrib>Hermann, Bruce</creatorcontrib><creatorcontrib>Cook, Cole J.</creatorcontrib><creatorcontrib>Hwang, Gyujoon</creatorcontrib><creatorcontrib>Dabbs, Kevin</creatorcontrib><creatorcontrib>Nair, Veena</creatorcontrib><creatorcontrib>Forseth, Courtney</creatorcontrib><creatorcontrib>Mathis, Jedidiah</creatorcontrib><creatorcontrib>Allen, Linda</creatorcontrib><creatorcontrib>Almane, Dace N.</creatorcontrib><creatorcontrib>Arkush, Karina</creatorcontrib><creatorcontrib>Birn, Rasmus</creatorcontrib><creatorcontrib>Conant, Lisa L.</creatorcontrib><creatorcontrib>DeYoe, Edgar A.</creatorcontrib><creatorcontrib>Felton, Elizabeth</creatorcontrib><creatorcontrib>Humphries, Colin J.</creatorcontrib><creatorcontrib>Kraegel, Peter</creatorcontrib><creatorcontrib>Maganti, Rama</creatorcontrib><creatorcontrib>Nencka, Andrew</creatorcontrib><creatorcontrib>Nwoke, Onyekachi</creatorcontrib><creatorcontrib>Raghavan, Manoj</creatorcontrib><creatorcontrib>Rozman, Megan</creatorcontrib><creatorcontrib>Shah, Umang</creatorcontrib><creatorcontrib>Sosa, Veronica N.</creatorcontrib><creatorcontrib>Struck, Aaron F.</creatorcontrib><creatorcontrib>Tellapragada, Neelima</creatorcontrib><creatorcontrib>Ustine, Candida</creatorcontrib><creatorcontrib>Ward, B. Douglas</creatorcontrib><creatorcontrib>Prabhakaran, Vivek</creatorcontrib><creatorcontrib>Binder, Jeffrey R.</creatorcontrib><creatorcontrib>Meyerand, Mary E.</creatorcontrib><title>Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
•Individuals with Temporal Lobe Epilepsy (TLE) show higher levels of neuroticism in the NEO-Five Factor Inventory.•Higher neuroticism is associated with earlier age of epilepsy onset.•Distributed reductions in cortical gray matter volumes were associated with increased neuroticism in TLE.•Hippocampal and amygdala volume were negatively associated with neuroticism in TLE.</description><subject>Adult</subject><subject>Amygdala - diagnostic imaging</subject><subject>Amygdala - physiology</subject><subject>Big 5 traits</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Connectome - methods</subject><subject>Epilepsy, Temporal Lobe - diagnostic imaging</subject><subject>Epilepsy, Temporal Lobe - psychology</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NEO-Five Factor Inventory</subject><subject>Neuroticism - physiology</subject><subject>Personality</subject><subject>Personality - physiology</subject><subject>Personality Inventory</subject><subject>Temporal lobe epilepsy</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGKFDEQDaK46-oXCJKjl2krnU66IyjIsKvCoh70HNLp6p0M3UmbZBb6780646AXT1VQr96reo-QlwwqBky-2Vcr9riramCqgraCWjwil0zUYiNAqsfnXsAFeZbSHoAxwdlTcsEZ71oAuCTrFzzEYLzJYXbWTNSGGHEyGRMNI10wpuDN5PJKczQuJ-o8zTgvIRbwFHqkuLgJl7S-pTfOD87fJTrGMNO8Q3p9mtFt8B5tEUH6LYZ9aZ-TJ6OZEr441Svy4-b6-_bT5vbrx8_bD7cb2wiVN2ZA1YytwIbXogMQnarHvpFKdVKikmCNGQVX0LFW8EEMUsre4shk0_d92_Mr8v7Iuxz6GQeLvjwy6SW62cRVB-P0vxPvdvou3GvZ8mKtKASvTwQx_Dxgynp2yeI0GY_hkHRdS9UAK7cVKD9CbQwpRRzPMgz0Q2h6r3-Hph9C09DqElrZevX3heedPykVwLsjAItP9w6jTtahtzi4WJzUQ3D_FfgF1EitDA</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Rivera Bonet, Charlene N.</creator><creator>Hermann, Bruce</creator><creator>Cook, Cole J.</creator><creator>Hwang, Gyujoon</creator><creator>Dabbs, Kevin</creator><creator>Nair, Veena</creator><creator>Forseth, Courtney</creator><creator>Mathis, Jedidiah</creator><creator>Allen, Linda</creator><creator>Almane, Dace N.</creator><creator>Arkush, Karina</creator><creator>Birn, Rasmus</creator><creator>Conant, Lisa L.</creator><creator>DeYoe, Edgar A.</creator><creator>Felton, Elizabeth</creator><creator>Humphries, Colin J.</creator><creator>Kraegel, Peter</creator><creator>Maganti, Rama</creator><creator>Nencka, Andrew</creator><creator>Nwoke, Onyekachi</creator><creator>Raghavan, Manoj</creator><creator>Rozman, Megan</creator><creator>Shah, Umang</creator><creator>Sosa, Veronica N.</creator><creator>Struck, Aaron F.</creator><creator>Tellapragada, Neelima</creator><creator>Ustine, Candida</creator><creator>Ward, B. 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Douglas</au><au>Prabhakaran, Vivek</au><au>Binder, Jeffrey R.</au><au>Meyerand, Mary E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>98</volume><issue>Pt A</issue><spage>220</spage><epage>227</epage><pages>220-227</pages><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
•Individuals with Temporal Lobe Epilepsy (TLE) show higher levels of neuroticism in the NEO-Five Factor Inventory.•Higher neuroticism is associated with earlier age of epilepsy onset.•Distributed reductions in cortical gray matter volumes were associated with increased neuroticism in TLE.•Hippocampal and amygdala volume were negatively associated with neuroticism in TLE.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31387000</pmid><doi>10.1016/j.yebeh.2019.07.025</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epilepsy & behavior, 2019-09, Vol.98 (Pt A), p.220-227 |
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| language | eng |
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| subjects | Adult Amygdala - diagnostic imaging Amygdala - physiology Big 5 traits Brain - diagnostic imaging Brain - physiology Connectome - methods Epilepsy, Temporal Lobe - diagnostic imaging Epilepsy, Temporal Lobe - psychology Female Gray Matter - diagnostic imaging Gray Matter - physiology Humans Magnetic Resonance Imaging - methods Male Middle Aged NEO-Five Factor Inventory Neuroticism - physiology Personality Personality - physiology Personality Inventory Temporal lobe epilepsy |
| title | Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project |
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